Sequential antibodies to potassium channels and glutamic acid decarboxylase in neuromyotonia.
A patient with thymoma-associated neuromyotonia and voltage-gated potassium channel (Kv1.2 and Kv1.6) antibodies by immunoprecipitation and rat brain immunolabeling was treated successfully with immunoadsorption and cyclophosphamide. Curiously, glutamic acid decarboxylase antibodies, absent at onset...
| Hauptverfasser: | , , , , , , , , , , |
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| Format: | Journal article |
| Sprache: | English |
| Veröffentlicht: |
2005
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| _version_ | 1826303241370992640 |
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| author | Antozzi, C Frassoni, C Vincent, A Regondi, M Andreetta, F Bernasconi, P Ciano, C Chang, T Cornelio, F Spreafico, R Mantegazza, R |
| author_facet | Antozzi, C Frassoni, C Vincent, A Regondi, M Andreetta, F Bernasconi, P Ciano, C Chang, T Cornelio, F Spreafico, R Mantegazza, R |
| author_sort | Antozzi, C |
| collection | OXFORD |
| description | A patient with thymoma-associated neuromyotonia and voltage-gated potassium channel (Kv1.2 and Kv1.6) antibodies by immunoprecipitation and rat brain immunolabeling was treated successfully with immunoadsorption and cyclophosphamide. Curiously, glutamic acid decarboxylase antibodies, absent at onset, appeared later. Stiff-person syndrome was absent, but fast blink reflex recovery suggested enhanced brainstem excitability. The range of antibodies produced in thymoma-associated neuromyotonia is richer, and the timing of antibody appearance more complex, than previously suspected. |
| first_indexed | 2024-03-07T05:59:40Z |
| format | Journal article |
| id | oxford-uuid:ebbbd814-07c2-4c14-8afe-e25fc93b5c08 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:59:40Z |
| publishDate | 2005 |
| record_format | dspace |
| spelling | oxford-uuid:ebbbd814-07c2-4c14-8afe-e25fc93b5c082022-03-27T11:12:03ZSequential antibodies to potassium channels and glutamic acid decarboxylase in neuromyotonia.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:ebbbd814-07c2-4c14-8afe-e25fc93b5c08EnglishSymplectic Elements at Oxford2005Antozzi, CFrassoni, CVincent, ARegondi, MAndreetta, FBernasconi, PCiano, CChang, TCornelio, FSpreafico, RMantegazza, RA patient with thymoma-associated neuromyotonia and voltage-gated potassium channel (Kv1.2 and Kv1.6) antibodies by immunoprecipitation and rat brain immunolabeling was treated successfully with immunoadsorption and cyclophosphamide. Curiously, glutamic acid decarboxylase antibodies, absent at onset, appeared later. Stiff-person syndrome was absent, but fast blink reflex recovery suggested enhanced brainstem excitability. The range of antibodies produced in thymoma-associated neuromyotonia is richer, and the timing of antibody appearance more complex, than previously suspected. |
| spellingShingle | Antozzi, C Frassoni, C Vincent, A Regondi, M Andreetta, F Bernasconi, P Ciano, C Chang, T Cornelio, F Spreafico, R Mantegazza, R Sequential antibodies to potassium channels and glutamic acid decarboxylase in neuromyotonia. |
| title | Sequential antibodies to potassium channels and glutamic acid decarboxylase in neuromyotonia. |
| title_full | Sequential antibodies to potassium channels and glutamic acid decarboxylase in neuromyotonia. |
| title_fullStr | Sequential antibodies to potassium channels and glutamic acid decarboxylase in neuromyotonia. |
| title_full_unstemmed | Sequential antibodies to potassium channels and glutamic acid decarboxylase in neuromyotonia. |
| title_short | Sequential antibodies to potassium channels and glutamic acid decarboxylase in neuromyotonia. |
| title_sort | sequential antibodies to potassium channels and glutamic acid decarboxylase in neuromyotonia |
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