RAD9 and RAD24 define two additive, interacting branches of the DNA damage checkpoint pathway in budding yeast normally required for Rad53 modification and activation.
In budding yeast, RAD9 and RAD24/RAD17/MEC3 are believed to function upstream of MEC1 and RAD53 in signalling the presence of DNA damage. Deletion of any one of these genes reduces the normal G1/S and G2/M checkpoint delays after UV irradiation, whereas in rad9Delta-rad24Delta cells the G1/S checkpo...
Main Authors: | de la Torre-Ruiz, MA, Green, C, Lowndes, N |
---|---|
Format: | Journal article |
Language: | English |
Published: |
1998
|
Similar Items
-
Budding yeast Rad9 is an ATP-dependent Rad53 activating machine.
by: Gilbert, C, et al.
Published: (2001) -
The budding yeast Rad9 checkpoint protein is subjected to Mec1/Tel1-dependent hyperphosphorylation and interacts with Rad53 after DNA damage.
by: Vialard, J, et al.
Published: (1998) -
The budding yeast Rad9 checkpoint complex: chaperone proteins are required for its function.
by: Gilbert, C, et al.
Published: (2003) -
A novel Rad24 checkpoint protein complex closely related to replication factor C.
by: Green, C, et al.
Published: (2000) -
DNA binding by the Rad9A subunit of the Rad9-Rad1-Hus1 complex.
by: Bor-Jang Hwang, et al.
Published: (2022-01-01)