Application of a proteolysis/mass spectrometry method for investigating the effects of inhibitors on hydroxylase structure.
Limited proteolysis coupled to matrix-assisted laser desorption/ionization (MALDI) mass spectrometric analyses can be used to screen for compounds that alter protein structure by monitoring stabilizing/destabilizing effects with respect to the rate and nature of proteolysis. When applied to prolyl h...
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Bibliographic Details
| Main Authors: |
Stubbs, C,
Loenarz, C,
Mecinović, J,
Yeoh, K,
Hindley, N,
Liénard, B,
Sobott, F,
Schofield, C,
Flashman, E |
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| Format: | Journal article
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| Language: | English |
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| Published: |
2009
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