The upregulation of Na+,K(+)-ATPase pump numbers in lymphocytes from the first-degree unaffected relatives of patients with manic depressive psychosis in response to in vitro lithium and sodium ethacrynate.
Patients with manic depressive disorder (DSM-III-R bipolar disorder) have an abnormality of the Na+,K(+)-ATPase pumps in their lymphocytes: the pump numbers do not upregulate to stimulation with lithium and ethacrynate. We have now investigated the in vitro adaptive responses of lymphocyte Na+,K(+)-...
| Autori principali: | , , , |
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| Natura: | Journal article |
| Lingua: | English |
| Pubblicazione: |
1995
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| _version_ | 1826303257030426624 |
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| author | Antia, I Smith, C Wood, A Aronson, J |
| author_facet | Antia, I Smith, C Wood, A Aronson, J |
| author_sort | Antia, I |
| collection | OXFORD |
| description | Patients with manic depressive disorder (DSM-III-R bipolar disorder) have an abnormality of the Na+,K(+)-ATPase pumps in their lymphocytes: the pump numbers do not upregulate to stimulation with lithium and ethacrynate. We have now investigated the in vitro adaptive responses of lymphocyte Na+,K(+)-ATPase pumps in the first-degree unaffected relatives of patients with a clear history of manic depressive disorder. The lymphocytes of the healthy relatives upregulated their Na+,K(+)-ATPase pumps normally, suggesting that the abnormal response that we have previously observed in patients with the disorder reflects a complex relation between the biochemical phenotype and the development of clinical symptoms. |
| first_indexed | 2024-03-07T05:59:54Z |
| format | Journal article |
| id | oxford-uuid:ebcf1e5c-aac5-4142-b231-f5dc86e70a22 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:59:54Z |
| publishDate | 1995 |
| record_format | dspace |
| spelling | oxford-uuid:ebcf1e5c-aac5-4142-b231-f5dc86e70a222022-03-27T11:12:40ZThe upregulation of Na+,K(+)-ATPase pump numbers in lymphocytes from the first-degree unaffected relatives of patients with manic depressive psychosis in response to in vitro lithium and sodium ethacrynate.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:ebcf1e5c-aac5-4142-b231-f5dc86e70a22EnglishSymplectic Elements at Oxford1995Antia, ISmith, CWood, AAronson, JPatients with manic depressive disorder (DSM-III-R bipolar disorder) have an abnormality of the Na+,K(+)-ATPase pumps in their lymphocytes: the pump numbers do not upregulate to stimulation with lithium and ethacrynate. We have now investigated the in vitro adaptive responses of lymphocyte Na+,K(+)-ATPase pumps in the first-degree unaffected relatives of patients with a clear history of manic depressive disorder. The lymphocytes of the healthy relatives upregulated their Na+,K(+)-ATPase pumps normally, suggesting that the abnormal response that we have previously observed in patients with the disorder reflects a complex relation between the biochemical phenotype and the development of clinical symptoms. |
| spellingShingle | Antia, I Smith, C Wood, A Aronson, J The upregulation of Na+,K(+)-ATPase pump numbers in lymphocytes from the first-degree unaffected relatives of patients with manic depressive psychosis in response to in vitro lithium and sodium ethacrynate. |
| title | The upregulation of Na+,K(+)-ATPase pump numbers in lymphocytes from the first-degree unaffected relatives of patients with manic depressive psychosis in response to in vitro lithium and sodium ethacrynate. |
| title_full | The upregulation of Na+,K(+)-ATPase pump numbers in lymphocytes from the first-degree unaffected relatives of patients with manic depressive psychosis in response to in vitro lithium and sodium ethacrynate. |
| title_fullStr | The upregulation of Na+,K(+)-ATPase pump numbers in lymphocytes from the first-degree unaffected relatives of patients with manic depressive psychosis in response to in vitro lithium and sodium ethacrynate. |
| title_full_unstemmed | The upregulation of Na+,K(+)-ATPase pump numbers in lymphocytes from the first-degree unaffected relatives of patients with manic depressive psychosis in response to in vitro lithium and sodium ethacrynate. |
| title_short | The upregulation of Na+,K(+)-ATPase pump numbers in lymphocytes from the first-degree unaffected relatives of patients with manic depressive psychosis in response to in vitro lithium and sodium ethacrynate. |
| title_sort | upregulation of na k atpase pump numbers in lymphocytes from the first degree unaffected relatives of patients with manic depressive psychosis in response to in vitro lithium and sodium ethacrynate |
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