The nuclear receptor PPARγ controls progressive macrophage polarization as a ligand-insensitive epigenomic ratchet of transcriptional memory

The nuclear receptor PPARγ controls progressive macrophage polarization as a ligand-insensitive epigenomic ratchet of transcriptional memory

Macrophages polarize into distinct phenotypes in response to complex environmental cues. We found that the nuclear receptor PPARγ drove robust phenotypic changes in macrophages upon repeated stimulation with interleukin (IL)-4. The functions of PPARγ on macrophage polarization in this setting were i...

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Bibliographische Detailangaben
Hauptverfasser: Daniel, B, Nagy, G, Czimmerer, Z, Horvath, A, Hammers, D, Cuaranta-Monroy, I, Poliska, S, Tzerpos, P, Kolostyak, Z, Hays, T, Patsalos, A, Houtman, R, Sauer, S, Francois-Deleuze, J, Rastinejad, F, Balint, B, Sweeney, H, Nagy, L
Format: Journal article
Sprache:English
Veröffentlicht: Elsevier 2018

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