A brave new world of RNA-binding proteins
RNA-binding proteins (RBPs) are typically thought of as proteins that bind RNA through one or multiple globular RNA-binding domains (RBDs) to change the fate or function of the bound RNAs. Several hundreds of such RBPs have been discovered and investigated over the years. Recent proteome-wide studie...
| Main Authors: | , , , |
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| Format: | Journal article |
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Nature Publishing Group
2018
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| Summary: | RNA-binding proteins (RBPs) are typically thought of as proteins that bind RNA through one or multiple globular RNA-binding domains (RBDs) to change the fate or function of the bound RNAs. Several hundreds of such RBPs have been discovered and investigated over the years. Recent proteome-wide studies have more than doubled the number of proteins implicated in RNA binding and uncovered hundreds of additional RBPs lacking classical RBDs. This review integrates these new RBPs and discusses their possible functions, including the notion that some may be regulated by RNA rather than exerting control over it. |
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