CaM kinase II-dependent mobilization of secretory granules underlies acetylcholine-induced stimulation of exocytosis in mouse pancreatic B-cells.

CaM kinase II-dependent mobilization of secretory granules underlies acetylcholine-induced stimulation of exocytosis in mouse pancreatic B-cells.

1. Measurements of cell capacitance were used to investigate the mechanisms by which acetylcholine (ACh) stimulates Ca2+-induced exocytosis in single insulin-secreting mouse pancreatic B-cells. 2. ACh (250 microM) increased exocytotic responses elicited by voltage-clamp depolarizations 2.3-fold. Thi...

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Bibliographische Detailangaben
Hauptverfasser:	Gromada, J, Høy, M, Renström, E, Bokvist, K, Eliasson, L, Göpel, S, Rorsman, P
Format:	Journal article
Sprache:	English
Veröffentlicht:	1999

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