Subtle role for adenylate kinase 1 in maintaining normal basal contractile function and metabolism in the murine heart

<br><strong>Aims: </strong>Adenylate kinase 1 (AK1) catalyses the reaction 2ADP ↔ ATP + AMP, extracting extra energy under metabolic stress and promoting energetic homeostasis. We hypothesised that increased AK1 activity would have negligible effects at rest, but protect against is...

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Main Authors: Zervou, S, McAndrew, DJ, Whittington, HJ, Lake, HA, Park, KC, Cha, KM, Ostrowski, PJ, Eykyn, TR, Schneider, JE, Neubauer, S, Lygate, CA
格式: Journal article
语言:English
出版: Frontiers Media 2021