Mutagenesis of conserved tryptophan residues within the receptor-binding domain of intimin: influence on binding activity and virulence.

Mutagenesis of conserved tryptophan residues within the receptor-binding domain of intimin: influence on binding activity and virulence.

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Intimate bacterial adhesion to intestinal epithelium is a pathogenic mechanism shared by several human and animal enteric pathogens, including enteropathogenic and enterohaemorrhagic Escherichia coli and Citrobacter rodentium. The proteins directly involved in this process are the outer-membrane adh...

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Bibliographic Details
Main Authors:	Reece, S, Simmons, C, Fitzhenry, R, Batchelor, M, Hale, C, Matthews, S, Phillips, A, Dougan, G, Frankel, G
Format:	Journal article
Language:	English
Published:	2002

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