Inhibition and activation by CD244 depends on CD2 and phospholipase C-gamma1.
Regulation by the NK and T cell surface receptor CD244 in mice and humans depends both on engagement at the cell surface by CD48 and intracellular interactions with SAP and EAT-2. Relevance to human disease by manipulating CD244 in mouse models is complicated by rodent CD2 also binding CD48. We dist...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2009
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