Beyond endoscopic mucosal healing in UC: histological remission better predicts corticosteroid use and hospitalisation over 6 years of follow-up
<strong>Backgroung:</strong> Endoscopic mucosal healing is an established treatment target for UC, yet the value of achieving histological remission remains unclear. <strong>Aims:</strong> To evaluate histological remission compared to endoscopic mucosal healing for predictin...
| Հիմնական հեղինակներ: | , , , , , , , , , , , |
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| Ձևաչափ: | Journal article |
| Լեզու: | English |
| Հրապարակվել է: |
BMJ Publishing Group
2015
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| _version_ | 1826303310569668608 |
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| author | Bryant, R Burger, D Delo, J Walsh, A Thomas, S von Herbay, A Buchel, O White, L Brain, O Keshav, S Warren, B Travis, S |
| author_facet | Bryant, R Burger, D Delo, J Walsh, A Thomas, S von Herbay, A Buchel, O White, L Brain, O Keshav, S Warren, B Travis, S |
| author_sort | Bryant, R |
| collection | OXFORD |
| description | <strong>Backgroung:</strong> Endoscopic mucosal healing is an established treatment target for UC, yet the value of achieving histological remission remains unclear. <strong>Aims:</strong> To evaluate histological remission compared to endoscopic mucosal healing for predicting patient outcomes in UC. <strong>Methods:</strong> Blinded assessment of endoscopic and histological measures of disease activity was performed on patients with established UC at baseline. Concordance and prognostic values of endoscopic mucosal healing (defined by Baron score ≤1) and histological remission (defined by Truelove and Richards' index) for predicting outcomes of corticosteroid use, hospitalisation and colectomy were determined over a median 6 years follow-up, including κ statistics and Cox regression multivariate analysis. <strong>Results:</strong> 91 patients with UC were followed up for a median 72 months (IQR 54-75 months). Overall, concordance between endoscopic and histological remission was moderate (κ=0.56, 95% CI 0.36 to 0.77); 24% patients had persistent inflammation despite endoscopic remission. Histological remission predicted corticosteroid use and acute severe colitis requiring hospitalisation over the follow-up period (HR 0.42 (0.2 to 0.9), p=0.02; HR 0.21 (0.1 to 0.7), p=0.02; respectively), whereas endoscopic mucosal healing did not (HR 0.86, 95% CI 0.5 to 1.7, p0.65; HR 0.83 95% CI 0.3 to 2.4, p0.74; respectively). <strong>Conclusions:</strong> Histological remission is a target distinct from endoscopic mucosal healing in UC and better predicts lower rates of corticosteroid use and acute severe colitis requiring hospitalisation, over a median of 6 years of follow-up. Our findings support the inclusion of histological indices in both UC clinical trials and practice, towards a target of 'complete remission'. |
| first_indexed | 2024-03-07T06:00:44Z |
| format | Journal article |
| id | oxford-uuid:ec190777-f5c0-4734-a074-fe133ec99b16 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:00:44Z |
| publishDate | 2015 |
| publisher | BMJ Publishing Group |
| record_format | dspace |
| spelling | oxford-uuid:ec190777-f5c0-4734-a074-fe133ec99b162022-03-27T11:14:53ZBeyond endoscopic mucosal healing in UC: histological remission better predicts corticosteroid use and hospitalisation over 6 years of follow-upJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:ec190777-f5c0-4734-a074-fe133ec99b16EnglishSymplectic Elements at OxfordBMJ Publishing Group2015Bryant, RBurger, DDelo, JWalsh, AThomas, Svon Herbay, ABuchel, OWhite, LBrain, OKeshav, SWarren, BTravis, S<strong>Backgroung:</strong> Endoscopic mucosal healing is an established treatment target for UC, yet the value of achieving histological remission remains unclear. <strong>Aims:</strong> To evaluate histological remission compared to endoscopic mucosal healing for predicting patient outcomes in UC. <strong>Methods:</strong> Blinded assessment of endoscopic and histological measures of disease activity was performed on patients with established UC at baseline. Concordance and prognostic values of endoscopic mucosal healing (defined by Baron score ≤1) and histological remission (defined by Truelove and Richards' index) for predicting outcomes of corticosteroid use, hospitalisation and colectomy were determined over a median 6 years follow-up, including κ statistics and Cox regression multivariate analysis. <strong>Results:</strong> 91 patients with UC were followed up for a median 72 months (IQR 54-75 months). Overall, concordance between endoscopic and histological remission was moderate (κ=0.56, 95% CI 0.36 to 0.77); 24% patients had persistent inflammation despite endoscopic remission. Histological remission predicted corticosteroid use and acute severe colitis requiring hospitalisation over the follow-up period (HR 0.42 (0.2 to 0.9), p=0.02; HR 0.21 (0.1 to 0.7), p=0.02; respectively), whereas endoscopic mucosal healing did not (HR 0.86, 95% CI 0.5 to 1.7, p0.65; HR 0.83 95% CI 0.3 to 2.4, p0.74; respectively). <strong>Conclusions:</strong> Histological remission is a target distinct from endoscopic mucosal healing in UC and better predicts lower rates of corticosteroid use and acute severe colitis requiring hospitalisation, over a median of 6 years of follow-up. Our findings support the inclusion of histological indices in both UC clinical trials and practice, towards a target of 'complete remission'. |
| spellingShingle | Bryant, R Burger, D Delo, J Walsh, A Thomas, S von Herbay, A Buchel, O White, L Brain, O Keshav, S Warren, B Travis, S Beyond endoscopic mucosal healing in UC: histological remission better predicts corticosteroid use and hospitalisation over 6 years of follow-up |
| title | Beyond endoscopic mucosal healing in UC: histological remission better predicts corticosteroid use and hospitalisation over 6 years of follow-up |
| title_full | Beyond endoscopic mucosal healing in UC: histological remission better predicts corticosteroid use and hospitalisation over 6 years of follow-up |
| title_fullStr | Beyond endoscopic mucosal healing in UC: histological remission better predicts corticosteroid use and hospitalisation over 6 years of follow-up |
| title_full_unstemmed | Beyond endoscopic mucosal healing in UC: histological remission better predicts corticosteroid use and hospitalisation over 6 years of follow-up |
| title_short | Beyond endoscopic mucosal healing in UC: histological remission better predicts corticosteroid use and hospitalisation over 6 years of follow-up |
| title_sort | beyond endoscopic mucosal healing in uc histological remission better predicts corticosteroid use and hospitalisation over 6 years of follow up |
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