Phenotypic consequences of somatic mutations in the ataxia-telangiectasia mutated gene in non-small cell lung cancer

Mutations in the Ataxia-telangiectasia mutated (ATM) gene are frequently found in human cancers, including non-small cell lung cancer (NSCLC). Loss of ATM function confers sensitivity to ionising radiation (IR) and topoisomerase inhibitors and may thus define a subset of cancer patients that could g...

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Hlavní autoři: Weber, A, Drobnitzky, N, Devery, A, Bokobza, S, Adams, R, Maughan, T, Ryan, A
Médium: Journal article
Jazyk:English
Vydáno: Impact Journals 2016