Structure activity relationship studies on rhodanines and derived enethiol inhibitors of metallo-β-lactamases

Structure activity relationship studies on rhodanines and derived enethiol inhibitors of metallo-β-lactamases

Metallo-β-lactamases (MBLs) enable bacterial resistance to almost all classes of β-lactam antibiotics. We report studies on enethiol containing MBL inhibitors, which were prepared by rhodanine hydrolysis. The enethiols inhibit MBLs from different subclasses. Crystallographic analyses reveal that the...

Bibliografske podrobnosti
Main Authors:	Zhang, D, Markoulides, MS, Stepanovs, D, Rydzik, AM, El-Hussein, A, Bon, C, Kamps, JJAG, Umland, K-D, Collins, PM, Cahill, ST, Wang, DY, von Delft, F, Brem, J, McDonough, MA, Schofield, CJ
Format:	Journal article
Jezik:	English
Izdano:	Elsevier 2018

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