Quantification and modeling of tripartite CD2-, CD58FC chimera (alefacept)-, and CD16-mediated cell adhesion.

Quantification and modeling of tripartite CD2-, CD58FC chimera (alefacept)-, and CD16-mediated cell adhesion.

Alefacept is a chimeric protein combining CD58 immunoglobulin-like domain 1 with human IgG1 Fc. Alefacept mediates adhesion by bridging CD2 on T cells to activating Fc receptors on effector cells, but the equilibrium binding parameters have not been determined. Alefacept mediated T cell killing by N...

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Bibliographic Details
Main Authors:	Dustin, M, Starr, T, Coombs, D, Majeau, G, Meier, W, Hochman, P, Douglass, A, Vale, R, Goldstein, B, Whitty, A
Format:	Journal article
Language:	English
Published:	2007

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