The mutagenic potential of 8-oxoG/single strand break-containing clusters depends on their relative positions.

The mutagenic potential of 8-oxoG/single strand break-containing clusters depends on their relative positions.

Show other versions (1)

The biological consequences of clusters containing a single strand break and base lesion(s) remain largely unknown. In the present study we determined the mutagenicities of two- and three-lesion clustered damage sites containing a 1-nucleotide gap (GAP) and 8-oxo-7,8-dihydroguanine(s) (8-oxoG(s)) in...

Full description

Bibliographic Details
Main Authors:	Noguchi, M, Urushibara, A, Yokoya, A, O'Neill, P, Shikazono, N
Format:	Journal article
Language:	English
Published:	2012

Similar Items

The mutagenic potential of 8-oxoG/single strand break-containing clusters depends on their relative positions
by: Noguchi, M, et al.
Published: (2012)

An AP site can protect against the mutagenic potential of 8-oxoG when present within a tandem clustered site in E. coli.
by: Cunniffe, S, et al.
Published: (2007)

8-OxoG retards the activity of the ligase III/XRCC1 complex during the repair of a single-strand break, when present within a clustered DNA damage site.
by: Lomax, M, et al.
Published: (2004)

Quantitation of 8-oxoG and strand breaks in pUC19 plasmid DNA after exposure to oxygen radical generating systems
by: Kennedy, Laura J. (Laura Jane)
Published: (2007)

Corrigendum to "Significance of DNA polymerase I in in vivo processing of clustered DNA damage" [Mut. Res.: Fundam. Mol. Mech. Mutagen. 749 (2013) 9-15]
by: Shikazono, N, et al.
Published: (2013)

Corrigendum to "Significance of DNA polymerase I in in vivo processing of clustered DNA damage" [Mut. Res.: Fundam. Mol. Mech. Mutagen. 749 (2013) 9-15]
by: Shikazono, N, et al.
Published: (2013)

Enhanced mutagenic potential of 8-oxo-7,8-dihydroguanine when present within a clustered DNA damage site.
by: Pearson, C, et al.
Published: (2004)

LET dependence of the yield of single-, double-strand breaks and base lesions in fully hydrated plasmid DNA films by 4He(2+) ion irradiation.
by: Urushibara, A, et al.
Published: (2008)

Significance of DNA polymerase I in in vivo processing of clustered DNA damage
by: Shikazono, N, et al.
Published: (2013)

Significance of DNA polymerase I in in vivo processing of clustered DNA damage.
by: Shikazono, N, et al.
Published: (2013)

Effects of hydration on the induction of strand breaks, base lesions, and clustered damage in DNA films by alpha-radiation
by: Yokoya, A, et al.
Published: (2003)

Significance of DNA polymerase I in in vivo processing of clustered DNA damage (vol 749, pg 9, 2013)
by: Shikazono, N, et al.
Published: (2013)

The roles of specific glycosylases in determining the mutagenic consequences of clustered DNA base damage.
by: Shikazono, N, et al.
Published: (2006)

Processing of thymine glycol in a clustered DNA damage site: mutagenic or cytotoxic.
by: Bellon, S, et al.
Published: (2009)

Effect of hydration on the induction of strand breaks and base lesions in plasmid DNA films by gamma-radiation.
by: Yokoya, A, et al.
Published: (2002)

Induction of DNA strand breaks, base lesions and clustered damage sites in hydrated plasmid DNA films by ultrasoft X rays around the phosphorus K edge.
by: Yokoya, A, et al.
Published: (2009)

Induction of persistent double strand breaks following multiphoton irradiation of cycling and G1-arrested mammalian cells-replication-induced double strand breaks.
by: Harper, J, et al.
Published: (2008)

DNA damage induced by the direct effect of He ion particles.
by: Urushibara, A, et al.
Published: (2006)

Processing of clustered DNA damage generates additional double-strand breaks in mammalian cells post-irradiation.
by: Gulston, M, et al.
Published: (2004)

Hierarchy of lesion processing governs the repair, double-strand break formation and mutability of three-lesion clustered DNA damage.
by: Eccles, L, et al.
Published: (2010)

Radical chemistry of 8-oxo-7,8-dihydro-2'-deoxyadenosine and 8-oxo-7,8-dihydro-2'-deoxyguanosine: a pulse radiolysis study.
by: Singh, T, et al.
Published: (2010)

Base excision repair processing of abasic site/single-strand break lesions within clustered damage sites associated with XRCC1 deficiency.
by: Mourgues, S, et al.
Published: (2007)

Biological consequences of potential repair intermediates of clustered base damage site in Escherichia coli.
by: Shikazono, N, et al.
Published: (2009)

Interplay of two major repair pathways in the processing of complex double-strand DNA breaks.
by: Dobbs, T, et al.
Published: (2008)

High-entropy effect breaking the oxo wall for selective high-valent metal–oxo species generation
by: Shi, Zhonglian, et al.
Published: (2025)

Efficiency of excision of 8-oxo-guanine within DNA clustered damage by XRS5 nuclear extracts and purified human OGG1 protein.
by: David-Cordonnier, M, et al.
Published: (2001)

Repair of tandem base lesions in DNA by human cell extracts generates persisting single-strand breaks.
by: Budworth, H, et al.
Published: (2005)

APE1-dependent repair of DNA single-strand breaks containing 3'-end 8-oxoguanine.
by: Parsons, J, et al.
Published: (2005)

Pathway utilization in response to a site-specific DNA double-strand break in fission yeast.
by: Prudden, J, et al.
Published: (2003)

5,6-Dihydrothymine impairs the base excision repair pathway of a closely opposed AP site or single-strand break.
by: Byrne, S, et al.
Published: (2009)

Persistent DNA strand breaks induce a CAF-like phenotype in normal fibroblasts
by: Legrand, A, et al.
Published: (2018)

DNA strand breaks at centromeres: friend or foe?
by: Graham, E, et al.
Published: (2023)

8-OxoA inhibits the incision of an AP site by the DNA glycosylases Fpg, Nth and the AP endonuclease HAP1.
by: Lomax, M, et al.
Published: (2005)

Dependence of the yield of DNA double-strand breaks in Chinese hamster V79-4 cells on the photon energy of ultrasoft X rays.
by: de Lara, C, et al.
Published: (2001)

Novel Smad proteins localize to IR-induced double-strand breaks: interplay between TGFβ and ATM pathways.
by: Wang, M, et al.
Published: (2013)

Targeted sequencing : single cells and single strand breaks
by: Ranu, Navpreet Singh
Published: (2019)

Detection and repair of single-strand breaks in nuclear DNA.
by: Cook, P, et al.
Published: (1976)

Co-ordination of DNA single strand break repair.
by: Dianov, G, et al.
Published: (2007)

DNA polymerase delta-dependent repair of DNA single strand breaks containing 3'-end proximal lesions.
by: Parsons, J, et al.
Published: (2007)

Acalypha wilkesiana extracts induce apoptosis by causing single strand and double strand DNA breaks
by: Lim, Su Wen, et al.
Published: (2011)