Direct enantio- and diastereoselective Mannich reactions of malonate and beta-keto esters with N-Boc and N-Cbz aldimines catalysed by a bifunctional cinchonine derivative.

A highly enantioselective Mannich reaction between malonate esters and N-Boc and N-Cbz aldimines, catalysed by a bifunctional cinchonine derivative, has been developed; extension of this methodology to encompass the use of 2-substituted-1,3-dicarbonyl nucleophiles allows the formation of adjacent st...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron: Tillman, A, Ye, J, Dixon, D
Fformat: Journal article
Iaith:English
Cyhoeddwyd: 2006