Structures of an MHC class I molecule from B21 chickens illustrate promiscuous peptide binding.
Little is known about the structure of major histocompatibility complex (MHC) molecules outside of mammals. Only one class I molecule in the chicken MHC is highly expressed, leading to strong genetic associations with infectious pathogens. Here, we report two structures of the MHC class I molecule B...
| Main Authors: | , , , , , , , , , , , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
2007
|
| _version_ | 1797102138673856512 |
|---|---|
| author | Koch, M Camp, S Collen, T Avila, D Salomonsen, J Wallny, H van Hateren, A Hunt, L Jacob, J Johnston, F Marston, D Shaw, I Dunbar, P Cerundolo, V Jones, E Kaufman, J |
| author_facet | Koch, M Camp, S Collen, T Avila, D Salomonsen, J Wallny, H van Hateren, A Hunt, L Jacob, J Johnston, F Marston, D Shaw, I Dunbar, P Cerundolo, V Jones, E Kaufman, J |
| author_sort | Koch, M |
| collection | OXFORD |
| description | Little is known about the structure of major histocompatibility complex (MHC) molecules outside of mammals. Only one class I molecule in the chicken MHC is highly expressed, leading to strong genetic associations with infectious pathogens. Here, we report two structures of the MHC class I molecule BF2*2101 from the B21 haplotype, which is known to confer resistance to Marek's disease caused by an oncogenic herpesvirus. The binding groove has an unusually large central cavity, which confers substantial conformational flexibility to the crucial residue Arg9, allowing remodeling of key peptide-binding sites. The coupled variation of anchor residues from the peptide, utilizing a charge-transfer system unprecedented in MHC molecules, allows peptides with conspicuously different sequences to be bound. This promiscuous binding extends our understanding of ways in which MHC class I molecules can present peptides to the immune system and might explain the resistance of the B21 haplotype to Marek's disease. |
| first_indexed | 2024-03-07T06:01:41Z |
| format | Journal article |
| id | oxford-uuid:ec67f61c-6f7e-46c1-b435-058fa78858ba |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:01:41Z |
| publishDate | 2007 |
| record_format | dspace |
| spelling | oxford-uuid:ec67f61c-6f7e-46c1-b435-058fa78858ba2022-03-27T11:17:18ZStructures of an MHC class I molecule from B21 chickens illustrate promiscuous peptide binding.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:ec67f61c-6f7e-46c1-b435-058fa78858baEnglishSymplectic Elements at Oxford2007Koch, MCamp, SCollen, TAvila, DSalomonsen, JWallny, Hvan Hateren, AHunt, LJacob, JJohnston, FMarston, DShaw, IDunbar, PCerundolo, VJones, EKaufman, JLittle is known about the structure of major histocompatibility complex (MHC) molecules outside of mammals. Only one class I molecule in the chicken MHC is highly expressed, leading to strong genetic associations with infectious pathogens. Here, we report two structures of the MHC class I molecule BF2*2101 from the B21 haplotype, which is known to confer resistance to Marek's disease caused by an oncogenic herpesvirus. The binding groove has an unusually large central cavity, which confers substantial conformational flexibility to the crucial residue Arg9, allowing remodeling of key peptide-binding sites. The coupled variation of anchor residues from the peptide, utilizing a charge-transfer system unprecedented in MHC molecules, allows peptides with conspicuously different sequences to be bound. This promiscuous binding extends our understanding of ways in which MHC class I molecules can present peptides to the immune system and might explain the resistance of the B21 haplotype to Marek's disease. |
| spellingShingle | Koch, M Camp, S Collen, T Avila, D Salomonsen, J Wallny, H van Hateren, A Hunt, L Jacob, J Johnston, F Marston, D Shaw, I Dunbar, P Cerundolo, V Jones, E Kaufman, J Structures of an MHC class I molecule from B21 chickens illustrate promiscuous peptide binding. |
| title | Structures of an MHC class I molecule from B21 chickens illustrate promiscuous peptide binding. |
| title_full | Structures of an MHC class I molecule from B21 chickens illustrate promiscuous peptide binding. |
| title_fullStr | Structures of an MHC class I molecule from B21 chickens illustrate promiscuous peptide binding. |
| title_full_unstemmed | Structures of an MHC class I molecule from B21 chickens illustrate promiscuous peptide binding. |
| title_short | Structures of an MHC class I molecule from B21 chickens illustrate promiscuous peptide binding. |
| title_sort | structures of an mhc class i molecule from b21 chickens illustrate promiscuous peptide binding |
| work_keys_str_mv | AT kochm structuresofanmhcclassimoleculefromb21chickensillustratepromiscuouspeptidebinding AT camps structuresofanmhcclassimoleculefromb21chickensillustratepromiscuouspeptidebinding AT collent structuresofanmhcclassimoleculefromb21chickensillustratepromiscuouspeptidebinding AT avilad structuresofanmhcclassimoleculefromb21chickensillustratepromiscuouspeptidebinding AT salomonsenj structuresofanmhcclassimoleculefromb21chickensillustratepromiscuouspeptidebinding AT wallnyh structuresofanmhcclassimoleculefromb21chickensillustratepromiscuouspeptidebinding AT vanhaterena structuresofanmhcclassimoleculefromb21chickensillustratepromiscuouspeptidebinding AT huntl structuresofanmhcclassimoleculefromb21chickensillustratepromiscuouspeptidebinding AT jacobj structuresofanmhcclassimoleculefromb21chickensillustratepromiscuouspeptidebinding AT johnstonf structuresofanmhcclassimoleculefromb21chickensillustratepromiscuouspeptidebinding AT marstond structuresofanmhcclassimoleculefromb21chickensillustratepromiscuouspeptidebinding AT shawi structuresofanmhcclassimoleculefromb21chickensillustratepromiscuouspeptidebinding AT dunbarp structuresofanmhcclassimoleculefromb21chickensillustratepromiscuouspeptidebinding AT cerundolov structuresofanmhcclassimoleculefromb21chickensillustratepromiscuouspeptidebinding AT jonese structuresofanmhcclassimoleculefromb21chickensillustratepromiscuouspeptidebinding AT kaufmanj structuresofanmhcclassimoleculefromb21chickensillustratepromiscuouspeptidebinding |