Strong TCR conservation and altered T cell cross-reactivity characterize a B*57-restricted immune response in HIV-1 infection.

Strong TCR conservation and altered T cell cross-reactivity characterize a B*57-restricted immune response in HIV-1 infection.

HLA-B*57 is associated with slower disease progression to AIDS, and CD8+ T cell responses to B*57-restricted epitopes are thought to contribute to this protective effect. In this study, we evaluate the B*57-restricted p24 KAFSPEVIPMF (KF11) immune response which is immunodominant during chronic infe...

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Main Authors: Gillespie, G, Stewart-Jones, G, Rengasamy, J, Beattie, T, Bwayo, J, Plummer, F, Kaul, R, Mcmichael, A, Easterbrook, P, Dong, T, Jones, E, Rowland-Jones, S
Formato: Journal article
Idioma:English
Publicado: 2006

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