Hypothermia in VGKC antibody-associated limbic encephalitis.
Voltage-gated potassium channel antibody (VGKC-Ab)-associated limbic encephalitis (LE) is a recently described syndrome that broadens the spectrum of immunotherapy-responsive central nervous system disorders. Limbic encephalitis is typically characterised by a sub-acute onset of disorientation, amne...
| Asıl Yazarlar: | , , , , , , , |
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| Materyal Türü: | Journal article |
| Dil: | English |
| Baskı/Yayın Bilgisi: |
2008
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| _version_ | 1826303375038218240 |
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| author | Jacob, S Irani, SR Rajabally, Y Grubneac, A Walters, R Yazaki, M Clover, L Vincent, A |
| author_facet | Jacob, S Irani, SR Rajabally, Y Grubneac, A Walters, R Yazaki, M Clover, L Vincent, A |
| author_sort | Jacob, S |
| collection | OXFORD |
| description | Voltage-gated potassium channel antibody (VGKC-Ab)-associated limbic encephalitis (LE) is a recently described syndrome that broadens the spectrum of immunotherapy-responsive central nervous system disorders. Limbic encephalitis is typically characterised by a sub-acute onset of disorientation, amnesia and seizures, but the clinical spectrum is not yet fully defined and the syndrome could be under-diagnosed. We here describe the clinical profile of four patients with VGKC-Ab-associated LE who had intermittent, episodic hypothermia. One of the patients also described a prodrome of severe neuropathic pain preceding the development of limbic symptoms. Both of these novel symptoms responded well to immunosuppressive therapy, with concurrent amelioration of amnesia/seizures. |
| first_indexed | 2024-03-07T06:01:43Z |
| format | Journal article |
| id | oxford-uuid:ec6af79e-e641-4662-94e8-e158b1de0bd1 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:01:43Z |
| publishDate | 2008 |
| record_format | dspace |
| spelling | oxford-uuid:ec6af79e-e641-4662-94e8-e158b1de0bd12022-03-27T11:17:20ZHypothermia in VGKC antibody-associated limbic encephalitis.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:ec6af79e-e641-4662-94e8-e158b1de0bd1EnglishSymplectic Elements at Oxford2008Jacob, SIrani, SRRajabally, YGrubneac, AWalters, RYazaki, MClover, LVincent, AVoltage-gated potassium channel antibody (VGKC-Ab)-associated limbic encephalitis (LE) is a recently described syndrome that broadens the spectrum of immunotherapy-responsive central nervous system disorders. Limbic encephalitis is typically characterised by a sub-acute onset of disorientation, amnesia and seizures, but the clinical spectrum is not yet fully defined and the syndrome could be under-diagnosed. We here describe the clinical profile of four patients with VGKC-Ab-associated LE who had intermittent, episodic hypothermia. One of the patients also described a prodrome of severe neuropathic pain preceding the development of limbic symptoms. Both of these novel symptoms responded well to immunosuppressive therapy, with concurrent amelioration of amnesia/seizures. |
| spellingShingle | Jacob, S Irani, SR Rajabally, Y Grubneac, A Walters, R Yazaki, M Clover, L Vincent, A Hypothermia in VGKC antibody-associated limbic encephalitis. |
| title | Hypothermia in VGKC antibody-associated limbic encephalitis. |
| title_full | Hypothermia in VGKC antibody-associated limbic encephalitis. |
| title_fullStr | Hypothermia in VGKC antibody-associated limbic encephalitis. |
| title_full_unstemmed | Hypothermia in VGKC antibody-associated limbic encephalitis. |
| title_short | Hypothermia in VGKC antibody-associated limbic encephalitis. |
| title_sort | hypothermia in vgkc antibody associated limbic encephalitis |
| work_keys_str_mv | AT jacobs hypothermiainvgkcantibodyassociatedlimbicencephalitis AT iranisr hypothermiainvgkcantibodyassociatedlimbicencephalitis AT rajaballyy hypothermiainvgkcantibodyassociatedlimbicencephalitis AT grubneaca hypothermiainvgkcantibodyassociatedlimbicencephalitis AT waltersr hypothermiainvgkcantibodyassociatedlimbicencephalitis AT yazakim hypothermiainvgkcantibodyassociatedlimbicencephalitis AT cloverl hypothermiainvgkcantibodyassociatedlimbicencephalitis AT vincenta hypothermiainvgkcantibodyassociatedlimbicencephalitis |