Classification and genomic diversity of enterically transmitted hepatitis viruses
Hepatitis A virus (HAV) and hepatitis E virus (HEV) are significant human pathogens and are responsible for a substantial proportion of cases of severe acute hepatitis worldwide. Genetically, both viruses are heterogeneous and are classified into several genotypes that differ in their geographical d...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
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Cold Spring Harbor Laboratory Press
2018
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| _version_ | 1826303375235350528 |
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| author | Smith, D Simmonds, P |
| author_facet | Smith, D Simmonds, P |
| author_sort | Smith, D |
| collection | OXFORD |
| description | Hepatitis A virus (HAV) and hepatitis E virus (HEV) are significant human pathogens and are responsible for a substantial proportion of cases of severe acute hepatitis worldwide. Genetically, both viruses are heterogeneous and are classified into several genotypes that differ in their geographical distribution and risk group association. There is, however, little evidence that variants of HAV or HEV differ antigenically or in their propensity to cause severe disease. Genetically more divergent but primarily hepatotropic variants of both HAV and HEV have been found in several mammalian species, those of HAV being classified into eight species within the genus Hepatovirus in the virus family Picornaviridae. HEV is classified as a member of the species Orthohepevirus A in the virus family Hepeviridae, a species that additionally contains viruses infecting pigs, rabbits, and a variety of other mammalian species. Other species (Orthohepevirus B–D) infect a wide range of other mammalian species including rodents and bats. |
| first_indexed | 2024-03-07T06:01:43Z |
| format | Journal article |
| id | oxford-uuid:ec6afce2-48ad-41e2-a985-750f2383ff68 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:01:43Z |
| publishDate | 2018 |
| publisher | Cold Spring Harbor Laboratory Press |
| record_format | dspace |
| spelling | oxford-uuid:ec6afce2-48ad-41e2-a985-750f2383ff682022-03-27T11:17:21ZClassification and genomic diversity of enterically transmitted hepatitis virusesJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:ec6afce2-48ad-41e2-a985-750f2383ff68EnglishSymplectic Elements at OxfordCold Spring Harbor Laboratory Press2018Smith, DSimmonds, PHepatitis A virus (HAV) and hepatitis E virus (HEV) are significant human pathogens and are responsible for a substantial proportion of cases of severe acute hepatitis worldwide. Genetically, both viruses are heterogeneous and are classified into several genotypes that differ in their geographical distribution and risk group association. There is, however, little evidence that variants of HAV or HEV differ antigenically or in their propensity to cause severe disease. Genetically more divergent but primarily hepatotropic variants of both HAV and HEV have been found in several mammalian species, those of HAV being classified into eight species within the genus Hepatovirus in the virus family Picornaviridae. HEV is classified as a member of the species Orthohepevirus A in the virus family Hepeviridae, a species that additionally contains viruses infecting pigs, rabbits, and a variety of other mammalian species. Other species (Orthohepevirus B–D) infect a wide range of other mammalian species including rodents and bats. |
| spellingShingle | Smith, D Simmonds, P Classification and genomic diversity of enterically transmitted hepatitis viruses |
| title | Classification and genomic diversity of enterically transmitted hepatitis viruses |
| title_full | Classification and genomic diversity of enterically transmitted hepatitis viruses |
| title_fullStr | Classification and genomic diversity of enterically transmitted hepatitis viruses |
| title_full_unstemmed | Classification and genomic diversity of enterically transmitted hepatitis viruses |
| title_short | Classification and genomic diversity of enterically transmitted hepatitis viruses |
| title_sort | classification and genomic diversity of enterically transmitted hepatitis viruses |
| work_keys_str_mv | AT smithd classificationandgenomicdiversityofentericallytransmittedhepatitisviruses AT simmondsp classificationandgenomicdiversityofentericallytransmittedhepatitisviruses |