The effects of chlordiazepoxide HCl administration upon punishment and conditioned suppression in the rat.
Rats were trained to lever press for sucrose on a random interval (RI) 64-s schedule. During a 55 min session there were four 3 min "intrusion periods" signalled by a flashing house-light. In experiment 1 there were two groups matched for baseline response rate. During the intrusion period...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1980
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| _version_ | 1797102142588190720 |
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| author | Rawlins, J Feldon, J Salmon, P Gray, J Garrud, P |
| author_facet | Rawlins, J Feldon, J Salmon, P Gray, J Garrud, P |
| author_sort | Rawlins, J |
| collection | OXFORD |
| description | Rats were trained to lever press for sucrose on a random interval (RI) 64-s schedule. During a 55 min session there were four 3 min "intrusion periods" signalled by a flashing house-light. In experiment 1 there were two groups matched for baseline response rate. During the intrusion periods one group received response-independent footshock on an independent RI 64 schedule; the other group received response-contingent shock on this schedule. Shock intensity was varied for each rat to match degree of response suppression between the two groups. Chlordiazepoxide HCl (CDP) in doses 0.5-5 mg/kg alleviated response suppression equally in both groups. Experiment II followed the same procedure, except that all animals had the same shock intensity, producing greater response suppression in the response-contingent shock groups. CDP alleviated response suppression more in the response-contingent shock groups, significantly so at 5 mg/kg, nonsignificantly at 1 mg/kg. These results suggest that previous reports that CDP differentially alleviates the response suppression produced by response-contingent shock are an artefact of rate dependency. |
| first_indexed | 2024-03-07T06:01:44Z |
| format | Journal article |
| id | oxford-uuid:ec6bafbf-c78d-4485-ace6-94f0bc23c09b |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:01:44Z |
| publishDate | 1980 |
| record_format | dspace |
| spelling | oxford-uuid:ec6bafbf-c78d-4485-ace6-94f0bc23c09b2022-03-27T11:17:31ZThe effects of chlordiazepoxide HCl administration upon punishment and conditioned suppression in the rat.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:ec6bafbf-c78d-4485-ace6-94f0bc23c09bEnglishSymplectic Elements at Oxford1980Rawlins, JFeldon, JSalmon, PGray, JGarrud, PRats were trained to lever press for sucrose on a random interval (RI) 64-s schedule. During a 55 min session there were four 3 min "intrusion periods" signalled by a flashing house-light. In experiment 1 there were two groups matched for baseline response rate. During the intrusion periods one group received response-independent footshock on an independent RI 64 schedule; the other group received response-contingent shock on this schedule. Shock intensity was varied for each rat to match degree of response suppression between the two groups. Chlordiazepoxide HCl (CDP) in doses 0.5-5 mg/kg alleviated response suppression equally in both groups. Experiment II followed the same procedure, except that all animals had the same shock intensity, producing greater response suppression in the response-contingent shock groups. CDP alleviated response suppression more in the response-contingent shock groups, significantly so at 5 mg/kg, nonsignificantly at 1 mg/kg. These results suggest that previous reports that CDP differentially alleviates the response suppression produced by response-contingent shock are an artefact of rate dependency. |
| spellingShingle | Rawlins, J Feldon, J Salmon, P Gray, J Garrud, P The effects of chlordiazepoxide HCl administration upon punishment and conditioned suppression in the rat. |
| title | The effects of chlordiazepoxide HCl administration upon punishment and conditioned suppression in the rat. |
| title_full | The effects of chlordiazepoxide HCl administration upon punishment and conditioned suppression in the rat. |
| title_fullStr | The effects of chlordiazepoxide HCl administration upon punishment and conditioned suppression in the rat. |
| title_full_unstemmed | The effects of chlordiazepoxide HCl administration upon punishment and conditioned suppression in the rat. |
| title_short | The effects of chlordiazepoxide HCl administration upon punishment and conditioned suppression in the rat. |
| title_sort | effects of chlordiazepoxide hcl administration upon punishment and conditioned suppression in the rat |
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