| Summary: | The histological evaluation is an essential tool used in the field of orthopedics to examine the biocompatibility, bone fracture healing, and articular cartilage repair of implants. The examination of bone biopsies near the implanted sample provides valuable information on bone structure, remodelling, and turnover. Recently, there have been significant advances in development of biodegradable magnesium and its alloys as orthopedic implant materials. However, there are currently no standardized methods available in the literature to reflect on to perform the histological evaluation of the magnesium alloys and the unique corrosive characteristic of magnesium often hinders the accurate observation. The purpose of this study was to evaluate the four most commonly used bone histological staining methods (Goldner's trichrome, Toludine blue, von Kossa with Gieson counterstain, Villanueva stain) to observe their effectiveness when used on magnesium
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