The emerging neurobiology of bipolar disorder
Bipolar disorder is a leading cause of global disability. Its biological basis is unknown, and its treatment unsatisfactory. Here we review two recent areas of progress. First, the discovery of risk genes and their implications, with a focus on voltage-gated calcium channels as part of the disease p...
| Главные авторы: | , , |
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| Формат: | Journal article |
| Опубликовано: |
Cell Press
2017
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| _version_ | 1826303388684386304 |
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| author | Harrison, PJ Geddes, JR Tunbridge, EM |
| author_facet | Harrison, PJ Geddes, JR Tunbridge, EM |
| author_sort | Harrison, PJ |
| collection | OXFORD |
| description | Bipolar disorder is a leading cause of global disability. Its biological basis is unknown, and its treatment unsatisfactory. Here we review two recent areas of progress. First, the discovery of risk genes and their implications, with a focus on voltage-gated calcium channels as part of the disease process and as a drug target. Second, facilitated by new technologies, it is increasingly apparent that the bipolar phenotype is more complex and nuanced than simply one of recurring manic and depressive episodes. One such feature is persistent mood instability, and efforts are underway to understand its mechanisms and its therapeutic potential. Bipolar disorder illustrates how psychiatry is being transformed by contemporary neuroscience, genomics, and digital approaches. |
| first_indexed | 2024-03-07T06:01:56Z |
| format | Journal article |
| id | oxford-uuid:ec7d63aa-2aec-4439-b63a-7c2d828d22db |
| institution | University of Oxford |
| last_indexed | 2024-03-07T06:01:56Z |
| publishDate | 2017 |
| publisher | Cell Press |
| record_format | dspace |
| spelling | oxford-uuid:ec7d63aa-2aec-4439-b63a-7c2d828d22db2022-03-27T11:17:55ZThe emerging neurobiology of bipolar disorderJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:ec7d63aa-2aec-4439-b63a-7c2d828d22dbSymplectic Elements at OxfordCell Press2017Harrison, PJGeddes, JRTunbridge, EMBipolar disorder is a leading cause of global disability. Its biological basis is unknown, and its treatment unsatisfactory. Here we review two recent areas of progress. First, the discovery of risk genes and their implications, with a focus on voltage-gated calcium channels as part of the disease process and as a drug target. Second, facilitated by new technologies, it is increasingly apparent that the bipolar phenotype is more complex and nuanced than simply one of recurring manic and depressive episodes. One such feature is persistent mood instability, and efforts are underway to understand its mechanisms and its therapeutic potential. Bipolar disorder illustrates how psychiatry is being transformed by contemporary neuroscience, genomics, and digital approaches. |
| spellingShingle | Harrison, PJ Geddes, JR Tunbridge, EM The emerging neurobiology of bipolar disorder |
| title | The emerging neurobiology of bipolar disorder |
| title_full | The emerging neurobiology of bipolar disorder |
| title_fullStr | The emerging neurobiology of bipolar disorder |
| title_full_unstemmed | The emerging neurobiology of bipolar disorder |
| title_short | The emerging neurobiology of bipolar disorder |
| title_sort | emerging neurobiology of bipolar disorder |
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