Combining tissue engineering and optical imaging approaches to explore interactions along the neuro-cardiac axis
Interactions along the neuro-cardiac axis are being explored with regard to their involvement in cardiac diseases, including catecholaminergic polymorphic ventricular tachycardia, hypertension, atrial fibrillation, long QT syndrome, and sudden death in epilepsy. Interrogation of the pathophysiology...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
The Royal Society
2020
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| _version_ | 1797102181441077248 |
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| author | Sigalas, C Cremer, M Winbo, A Bose, S Bose, S Ashton, J Ashton, J Rebecca-Ann Burton |
| author_facet | Sigalas, C Cremer, M Winbo, A Bose, S Bose, S Ashton, J Ashton, J Rebecca-Ann Burton |
| author_sort | Sigalas, C |
| collection | OXFORD |
| description | Interactions along the neuro-cardiac axis are being explored with regard to their
involvement in cardiac diseases, including catecholaminergic polymorphic ventricular
tachycardia, hypertension, atrial fibrillation, long QT syndrome, and sudden death in epilepsy.
Interrogation of the pathophysiology and pathogenesis of neuro-cardiac diseases in animal
models present challenges resulting from species differences, phenotypic variation,
developmental effects, and limited availability of data relevant at both the tissue and cellular
level. In contrast, tissue engineered models containing cardiomyocytes and peripheral
sympathetic and parasympathetic neurons afford characterization of cellular and tissue level
behaviours whilst maintaining precise control over developmental conditions, cellular
genotype and phenotype. Such approaches are uniquely suited to long term, high-throughput
characterization utilising optical recording techniques with the potential for increased
translational benefit compared to more established techniques. Furthermore, tissue
engineered constructs provide an intermediary between whole animal/tissue experiments
and in silico models. This paper reviews the advantages of tissue engineering methods of
multiple cell types and optical imaging techniques for the characterization of neuro-cardiac
diseases. |
| first_indexed | 2024-03-07T06:02:19Z |
| format | Journal article |
| id | oxford-uuid:eca0e4aa-4eb3-4fa5-890d-127345b3d7ea |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:02:19Z |
| publishDate | 2020 |
| publisher | The Royal Society |
| record_format | dspace |
| spelling | oxford-uuid:eca0e4aa-4eb3-4fa5-890d-127345b3d7ea2022-03-27T11:18:55ZCombining tissue engineering and optical imaging approaches to explore interactions along the neuro-cardiac axisJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:eca0e4aa-4eb3-4fa5-890d-127345b3d7eaEnglishSymplectic ElementsThe Royal Society2020Sigalas, CCremer, MWinbo, ABose, SBose, SAshton, JAshton, JRebecca-Ann BurtonInteractions along the neuro-cardiac axis are being explored with regard to their involvement in cardiac diseases, including catecholaminergic polymorphic ventricular tachycardia, hypertension, atrial fibrillation, long QT syndrome, and sudden death in epilepsy. Interrogation of the pathophysiology and pathogenesis of neuro-cardiac diseases in animal models present challenges resulting from species differences, phenotypic variation, developmental effects, and limited availability of data relevant at both the tissue and cellular level. In contrast, tissue engineered models containing cardiomyocytes and peripheral sympathetic and parasympathetic neurons afford characterization of cellular and tissue level behaviours whilst maintaining precise control over developmental conditions, cellular genotype and phenotype. Such approaches are uniquely suited to long term, high-throughput characterization utilising optical recording techniques with the potential for increased translational benefit compared to more established techniques. Furthermore, tissue engineered constructs provide an intermediary between whole animal/tissue experiments and in silico models. This paper reviews the advantages of tissue engineering methods of multiple cell types and optical imaging techniques for the characterization of neuro-cardiac diseases. |
| spellingShingle | Sigalas, C Cremer, M Winbo, A Bose, S Bose, S Ashton, J Ashton, J Rebecca-Ann Burton Combining tissue engineering and optical imaging approaches to explore interactions along the neuro-cardiac axis |
| title | Combining tissue engineering and optical imaging approaches to explore interactions along the neuro-cardiac axis |
| title_full | Combining tissue engineering and optical imaging approaches to explore interactions along the neuro-cardiac axis |
| title_fullStr | Combining tissue engineering and optical imaging approaches to explore interactions along the neuro-cardiac axis |
| title_full_unstemmed | Combining tissue engineering and optical imaging approaches to explore interactions along the neuro-cardiac axis |
| title_short | Combining tissue engineering and optical imaging approaches to explore interactions along the neuro-cardiac axis |
| title_sort | combining tissue engineering and optical imaging approaches to explore interactions along the neuro cardiac axis |
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