Diabetic peripheral neuropathy: advances in diagnosis and strategies for screening and early intervention
Diabetic peripheral neuropathy (DPN) is a common complication of both type 1 and 2 diabetes. It is a leading cause of lower-limb amputation and disabling neuropathic pain. Amputations in patients with diabetes have a devastating effect on quality of life and are associated with an alarmingly low lif...
| मुख्य लेखकों: | , , , , , , |
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| स्वरूप: | Journal article |
| भाषा: | English |
| प्रकाशित: |
Elsevier
2019
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| _version_ | 1826310663596670976 |
|---|---|
| author | Selvarajah, D Kar, D Khunti, K Davies, MJ Scott, AR Walker, J Tesfaye, S |
| author_facet | Selvarajah, D Kar, D Khunti, K Davies, MJ Scott, AR Walker, J Tesfaye, S |
| author_sort | Selvarajah, D |
| collection | OXFORD |
| description | Diabetic peripheral neuropathy (DPN) is a common complication of both type 1 and 2 diabetes. It is a leading cause of lower-limb amputation and disabling neuropathic pain. Amputations in patients with diabetes have a devastating effect on quality of life and are associated with an alarmingly low life expectancy (on average only 2 years from the amputation). Amputation also places a substantial financial burden on health-care systems and society in general. With the introduction of national diabetes eye screening programmes, the prevalence of blindness in working-age adults is falling. This is not the case, however, with diabetes related amputations. In this Review, we appraise innovative point-of-care devices that enable the early diagnosis of DPN and assess the evidence for early risk factor-based management strategies to reduce the incidence and slow the progression of DPN. We also propose a framework for screening and early multifactorial interventions as the best prospect for preventing or halting DPN and its devastating sequelae. |
| first_indexed | 2024-03-07T07:55:15Z |
| format | Journal article |
| id | oxford-uuid:eca36e9f-c7c8-4e09-b0f4-f9d1902c802b |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T07:55:15Z |
| publishDate | 2019 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:eca36e9f-c7c8-4e09-b0f4-f9d1902c802b2023-08-10T14:36:02ZDiabetic peripheral neuropathy: advances in diagnosis and strategies for screening and early interventionJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:eca36e9f-c7c8-4e09-b0f4-f9d1902c802bEnglishSymplectic ElementsElsevier2019Selvarajah, DKar, DKhunti, KDavies, MJScott, ARWalker, JTesfaye, SDiabetic peripheral neuropathy (DPN) is a common complication of both type 1 and 2 diabetes. It is a leading cause of lower-limb amputation and disabling neuropathic pain. Amputations in patients with diabetes have a devastating effect on quality of life and are associated with an alarmingly low life expectancy (on average only 2 years from the amputation). Amputation also places a substantial financial burden on health-care systems and society in general. With the introduction of national diabetes eye screening programmes, the prevalence of blindness in working-age adults is falling. This is not the case, however, with diabetes related amputations. In this Review, we appraise innovative point-of-care devices that enable the early diagnosis of DPN and assess the evidence for early risk factor-based management strategies to reduce the incidence and slow the progression of DPN. We also propose a framework for screening and early multifactorial interventions as the best prospect for preventing or halting DPN and its devastating sequelae. |
| spellingShingle | Selvarajah, D Kar, D Khunti, K Davies, MJ Scott, AR Walker, J Tesfaye, S Diabetic peripheral neuropathy: advances in diagnosis and strategies for screening and early intervention |
| title | Diabetic peripheral neuropathy: advances in diagnosis and strategies for screening and early intervention |
| title_full | Diabetic peripheral neuropathy: advances in diagnosis and strategies for screening and early intervention |
| title_fullStr | Diabetic peripheral neuropathy: advances in diagnosis and strategies for screening and early intervention |
| title_full_unstemmed | Diabetic peripheral neuropathy: advances in diagnosis and strategies for screening and early intervention |
| title_short | Diabetic peripheral neuropathy: advances in diagnosis and strategies for screening and early intervention |
| title_sort | diabetic peripheral neuropathy advances in diagnosis and strategies for screening and early intervention |
| work_keys_str_mv | AT selvarajahd diabeticperipheralneuropathyadvancesindiagnosisandstrategiesforscreeningandearlyintervention AT kard diabeticperipheralneuropathyadvancesindiagnosisandstrategiesforscreeningandearlyintervention AT khuntik diabeticperipheralneuropathyadvancesindiagnosisandstrategiesforscreeningandearlyintervention AT daviesmj diabeticperipheralneuropathyadvancesindiagnosisandstrategiesforscreeningandearlyintervention AT scottar diabeticperipheralneuropathyadvancesindiagnosisandstrategiesforscreeningandearlyintervention AT walkerj diabeticperipheralneuropathyadvancesindiagnosisandstrategiesforscreeningandearlyintervention AT tesfayes diabeticperipheralneuropathyadvancesindiagnosisandstrategiesforscreeningandearlyintervention |