Publisher's note: Growth, collapse, and stalling in a mechanical model for neurite motility [Phys. Rev. E 93, 032410 (2016)]

This corrects the article DOI: 10.1103/PhysRevE.93.032410. Neurites, the long cellular protrusions that form the routes of the neuronal network, are capable of actively extending during early morphogenesis or regenerating after trauma. To perform this task, they rely on their cytoskeleton for mechan...

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Bibliographic Details
Main Authors: Recho, P, Jerusalem, A, Goriely, A
Format: Journal article
Language:English
Published: American Physical Society 2016
Description
Summary:This corrects the article DOI: 10.1103/PhysRevE.93.032410. Neurites, the long cellular protrusions that form the routes of the neuronal network, are capable of actively extending during early morphogenesis or regenerating after trauma. To perform this task, they rely on their cytoskeleton for mechanical support. In this paper, we present a three-component active gel model that describes neurites in the three robust mechanical states observed experimentally: collapsed, static, and motile. These states arise from an interplay between the physical forces driven by growth of the microtubule-rich inner core of the neurite and the acto-myosin contractility of its surrounding cortical membrane. In particular, static states appear as a mechanical traction or compression balance of these two parallel structures. The model predicts how the response of a neurite to a towing force depends on the force magnitude and recovers the response of neurites to several drug treatments that modulate the cytoskeleton active and passive properties.