Publisher's note: Growth, collapse, and stalling in a mechanical model for neurite motility [Phys. Rev. E 93, 032410 (2016)]
This corrects the article DOI: 10.1103/PhysRevE.93.032410. Neurites, the long cellular protrusions that form the routes of the neuronal network, are capable of actively extending during early morphogenesis or regenerating after trauma. To perform this task, they rely on their cytoskeleton for mechan...
| Main Authors: | , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
American Physical Society
2016
|
| _version_ | 1797102185959391232 |
|---|---|
| author | Recho, P Jerusalem, A Goriely, A |
| author_facet | Recho, P Jerusalem, A Goriely, A |
| author_sort | Recho, P |
| collection | OXFORD |
| description | This corrects the article DOI: 10.1103/PhysRevE.93.032410. Neurites, the long cellular protrusions that form the routes of the neuronal network, are capable of actively extending during early morphogenesis or regenerating after trauma. To perform this task, they rely on their cytoskeleton for mechanical support. In this paper, we present a three-component active gel model that describes neurites in the three robust mechanical states observed experimentally: collapsed, static, and motile. These states arise from an interplay between the physical forces driven by growth of the microtubule-rich inner core of the neurite and the acto-myosin contractility of its surrounding cortical membrane. In particular, static states appear as a mechanical traction or compression balance of these two parallel structures. The model predicts how the response of a neurite to a towing force depends on the force magnitude and recovers the response of neurites to several drug treatments that modulate the cytoskeleton active and passive properties. |
| first_indexed | 2024-03-07T06:02:22Z |
| format | Journal article |
| id | oxford-uuid:eca6e7af-1118-46be-a32e-28df97640271 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:02:22Z |
| publishDate | 2016 |
| publisher | American Physical Society |
| record_format | dspace |
| spelling | oxford-uuid:eca6e7af-1118-46be-a32e-28df976402712022-03-27T11:19:03ZPublisher's note: Growth, collapse, and stalling in a mechanical model for neurite motility [Phys. Rev. E 93, 032410 (2016)]Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:eca6e7af-1118-46be-a32e-28df97640271EnglishSymplectic Elements at OxfordAmerican Physical Society2016Recho, PJerusalem, AGoriely, AThis corrects the article DOI: 10.1103/PhysRevE.93.032410. Neurites, the long cellular protrusions that form the routes of the neuronal network, are capable of actively extending during early morphogenesis or regenerating after trauma. To perform this task, they rely on their cytoskeleton for mechanical support. In this paper, we present a three-component active gel model that describes neurites in the three robust mechanical states observed experimentally: collapsed, static, and motile. These states arise from an interplay between the physical forces driven by growth of the microtubule-rich inner core of the neurite and the acto-myosin contractility of its surrounding cortical membrane. In particular, static states appear as a mechanical traction or compression balance of these two parallel structures. The model predicts how the response of a neurite to a towing force depends on the force magnitude and recovers the response of neurites to several drug treatments that modulate the cytoskeleton active and passive properties. |
| spellingShingle | Recho, P Jerusalem, A Goriely, A Publisher's note: Growth, collapse, and stalling in a mechanical model for neurite motility [Phys. Rev. E 93, 032410 (2016)] |
| title | Publisher's note: Growth, collapse, and stalling in a mechanical model for neurite motility [Phys. Rev. E 93, 032410 (2016)] |
| title_full | Publisher's note: Growth, collapse, and stalling in a mechanical model for neurite motility [Phys. Rev. E 93, 032410 (2016)] |
| title_fullStr | Publisher's note: Growth, collapse, and stalling in a mechanical model for neurite motility [Phys. Rev. E 93, 032410 (2016)] |
| title_full_unstemmed | Publisher's note: Growth, collapse, and stalling in a mechanical model for neurite motility [Phys. Rev. E 93, 032410 (2016)] |
| title_short | Publisher's note: Growth, collapse, and stalling in a mechanical model for neurite motility [Phys. Rev. E 93, 032410 (2016)] |
| title_sort | publisher s note growth collapse and stalling in a mechanical model for neurite motility phys rev e 93 032410 2016 |
| work_keys_str_mv | AT rechop publishersnotegrowthcollapseandstallinginamechanicalmodelforneuritemotilityphysreve930324102016 AT jerusalema publishersnotegrowthcollapseandstallinginamechanicalmodelforneuritemotilityphysreve930324102016 AT gorielya publishersnotegrowthcollapseandstallinginamechanicalmodelforneuritemotilityphysreve930324102016 |