Lithium plus valproate combination therapy versus monotherapy for relapse prevention in bipolar I disorder (BALANCE): a randomised open-label trial.

Lithium plus valproate combination therapy versus monotherapy for relapse prevention in bipolar I disorder (BALANCE): a randomised open-label trial.

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BACKGROUND: Lithium carbonate and valproate semisodium are both recommended as monotherapy for prevention of relapse in bipolar disorder, but are not individually fully effective in many patients. If combination therapy with both agents is better than monotherapy, many relapses and consequent disabi...

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Bibliographic Details
Main Authors: Geddes, J, Goodwin, G, Rendell, J, Azorin, J, Cipriani, A, Ostacher, M, Morriss, R, Alder, N, Juszczak, E
Format: Journal article
Language:English
Published: 2010

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