Comprehensively profiling the chromatin architecture of tissue restricted antigen expression in thymic epithelial cells over development

Comprehensively profiling the chromatin architecture of tissue restricted antigen expression in thymic epithelial cells over development

Thymic epithelial cells (TEC) effect crucial roles in thymopoiesis including the control of negative thymocyte selection. This process depends on their capacity to express promiscuously genes encoding tissue-restricted antigens. This competence is accomplished in medullary TEC (mTEC) in part by the...

Full description

Bibliographic Details
Main Authors:	Handel, A, Shikama-Dorn, N, Zhanybekova, S, Maio, S, Graedel, A, Zuklys, S, Ponting, C, Hollander, G
Format:	Journal article
Published:	Frontiers Media 2018

Similar Items

Foxn1 regulates key target genes essential for T cell development in postnatal thymic epithelial cells.
by: Žuklys, S, et al.
Published: (2016)

Foxn1 regulates in postnatal thymic epithelial cells key target genes essential for T cell development
by: Žuklys, S, et al.
Published: (2016)

Population and single-cell genomics reveal the Aire dependency, relief from Polycomb silencing, and distribution of self-antigen expression in thymic epithelia.
by: Sansom, S, et al.
Published: (2014)

Aire-expressing thymic medullary epithelial cells originate from β5t-expressing progenitor cells.
by: Ohigashi, I, et al.
Published: (2013)

Comment on "Identification of an intronic regulatory element necessary for tissue-specific expression of Foxn1 in thymic epithelial cells"
by: Handel, AE, et al.
Published: (2019)

TGF- 2signaling in thymic epithelial cells regulates thymic involution and postirradiation reconstitution
by: Hauri-Hohl, M, et al.
Published: (2008)

TGF-beta signaling in thymic epithelial cells regulates thymic involution and postirradiation reconstitution.
by: Hauri-Hohl, M, et al.
Published: (2008)

Dynamic spatio-temporal contribution of single β5t+ cortical epithelial precursors to the thymus medulla
by: Mayer, C, et al.
Published: (2016)

Stabilized beta-catenin in thymic epithelial cells blocks thymus development and function.
by: Zuklys, S, et al.
Published: (2009)

Biologically indeterminate yet ordered promiscuous gene expression in single medullary thymic epithelial cells
by: Dhalla, F, et al.
Published: (2019)

Maintenance of a normal thymic microenvironment and T-cell homeostasis require Smad4-mediated signaling in thymic epithelial cells.
by: Jeker, LT, et al.
Published: (2008)

The role of histone 3 lysine 27 trimethylation in thymic epithelial cell development and function
by: Graedel, A
Published: (2018)

Indispensable epigenetic control of thymic epithelial cell development and function by polycomb repressive complex 2
by: Barthlott, T, et al.
Published: (2021)

Thymic epithelial organoids mediate T-cell development
by: Hübscher, T, et al.
Published: (2024)

Epithelial cytoprotection sustains ectopic expression of tissue-restricted antigens in the thymus during murine acute GVHD.
by: Dertschnig, S, et al.
Published: (2013)

Sonic Hedgehog regulates thymic epithelial cell differentiation
by: Saldana, J, et al.
Published: (2016)

Adult thymic medullary epithelium is maintained and regenerated by linage-restricted cells rather than bipotent progenitors
by: Ohigashi, I, et al.
Published: (2015)

The role of thymic tolerance in CNS autoimmune disease
by: Handel, A, et al.
Published: (2018)

The role of thymic tolerance in CNS autoimmune disease
by: Handel, A, et al.
Published: (2018)

Despite high levels of expression in thymic epithelial cells, miR-181a1 and miR-181b1 are not required for thymic development
by: Stefanski, H, et al.
Published: (2018)

TRAF3 enforces the requirement for T cell cross-talk in thymic medullary epithelial development.
by: Jenkinson, SR, et al.
Published: (2013)

The thymic epithelial microRNA network elevates the threshold for infection-associated thymic involution via miR-29a mediated suppression of the IFN-α receptor.
by: Papadopoulou, A, et al.
Published: (2012)

IL-7 produced by thymic epithelial cells plays a major role in the development of thymocytes and TCRγδ+ intraepithelial lymphocytes.
by: Shitara, S, et al.
Published: (2013)

Keratinocyte growth factor (KGF) enhances postnatal T-cell development via enhancements in proliferation and function of thymic epithelial cells.
by: Rossi, S, et al.
Published: (2007)

Spatial (Tbata) expression in mature medullary thymic epithelial cells.
by: Saade, M, et al.
Published: (2010)

A regulatory role for TGF-β signaling in the establishment and function of the thymic medulla.
by: Hauri-Hohl, M, et al.
Published: (2014)

A regulatory role for TGF-β signaling in the establishment and function of the thymic medulla
by: Hauri-Hohl, M, et al.
Published: (2014)

Thymic epithelial cell support of thymopoiesis does not require Klotho
by: Xing, Y, et al.
Published: (2018)

Retinoic acid signaling in thymic epithelial cells regulates thymopoiesis
by: Wendland, K, et al.
Published: (2018)

Thymic cysts originate from Foxn1 positive thymic medullary epithelium.
by: Vroegindeweij, E, et al.
Published: (2010)

A transcriptomics-based investigation of the landscape and mechanisms of self-antigen splicing in thymic epithelial cells
by: Jansen, K
Published: (2019)

Diversity in cortical thymic epithelial cells occurs through loss of a Foxn1-dependent gene signature driven by stage-specific thymocyte cross-talk
by: White, AJ, et al.
Published: (2023)

The immunopathology of thymic GVHD.
by: Krenger, W, et al.
Published: (2008)

Developmental dynamics of the neural crest-mesenchymal axis in creating the thymic microenvironment
by: Handel, A, et al.
Published: (2022)

Requirement of stat3 signaling in the postnatal development of thymic medullary epithelial cells
by: Satoh, R, et al.
Published: (2016)

MicroRNAs control the maintenance of thymic epithelia and their competence for T lineage commitment and thymocyte selection.
by: Zuklys, S, et al.
Published: (2012)

Lentiviral Vector-Mediated Induction of Oct4 Expression in Primary Adult Mouse Thymic Epithelial Cells To Generate Tools for Gene Replacement and Tissue Regeneration
by: Bosticardo, M, et al.
Published: (2014)

Delta-like 4 is indispensable in thymic environment specific for T cell development.
by: Hozumi, K, et al.
Published: (2008)

A critical epithelial survival axis regulated by MCL-1 maintains thymic function in mice
by: Jain, R, et al.
Published: (2017)

Autoantigen-specific interactions with CD4+ thymocytes control mature medullary thymic epithelial cell cellularity.
by: Irla, M, et al.
Published: (2008)