Promiscuous targeting of bromodomains by Bromosporine identifies BET proteins as master regulators of primary transcription response in leukemia

Promiscuous targeting of bromodomains by Bromosporine identifies BET proteins as master regulators of primary transcription response in leukemia

Bromodomains (BRDs) have emerged as compelling targets for cancer therapy. The development of selective and potent BET inhibitors and their significant activity in diverse tumor models has rapidly translated into clinical studies and has motivated drug development efforts targeting non-BET BRDs. How...

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Bibliographic Details
Main Authors: Picaud, S, Leonards, K, Lambert, J, Dovey, O, Wells, C, Fedorov, O, Monteiro, O, Fujisawa, T, Wang, C, Lingard, H, Tallant, C, Nikbin, N, Guetzoyan, L, Ingham, R, Ley, S, Brennan, P, Muller, S, Samsonova, A, Gingras, A, Schwaller, J, Vassiliou, G, Knapp, S, Filippakopoulos, P
Format: Journal article
Published: American Association for the Advancement of Science 2016

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