Functional analysis of POLE exonuclease domain mutations in cancer

Functional analysis of POLE exonuclease domain mutations in cancer

<p><em>POLE</em> encodes the polymerase and exonuclease domains of the leading strand replicase, DNA polymerase ε. Somatic and germline <em>POLE</em> exonuclease domain mutations (EDMs) occur in colorectal and endometrial cancer and are associated with tumour ultramutat...

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Bibliographic Details
Main Author:	Rayner, E
Other Authors:	Church, D
Format:	Thesis
Published:	2019

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