Functional analysis of POLE exonuclease domain mutations in cancer
<p><em>POLE</em> encodes the polymerase and exonuclease domains of the leading strand replicase, DNA polymerase ε. Somatic and germline <em>POLE</em> exonuclease domain mutations (EDMs) occur in colorectal and endometrial cancer and are associated with tumour ultramutat...
| المؤلف الرئيسي: | |
|---|---|
| مؤلفون آخرون: | |
| التنسيق: | أطروحة |
| منشور في: |
2019
|