Functional analysis of POLE exonuclease domain mutations in cancer

Functional analysis of POLE exonuclease domain mutations in cancer

<p><em>POLE</em> encodes the polymerase and exonuclease domains of the leading strand replicase, DNA polymerase ε. Somatic and germline <em>POLE</em> exonuclease domain mutations (EDMs) occur in colorectal and endometrial cancer and are associated with tumour ultramutat...

Deskribapen osoa

Xehetasun bibliografikoak
Egile nagusia:	Rayner, E
Beste egile batzuk:	Church, D
Formatua:	Thesis
Argitaratua:	2019

Antzeko izenburuak

Prognostic benefit of POLE exonuclease domain mutations in endometrial cancer cannot be explained by increased sensitivity to adjuvant treatment strategies
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Argitaratua: (2017)

Somatic POLE exonuclease domain mutations elicit enhanced intratumoral immune responses in stage II colorectal cancer
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Argitaratua: (2020-10-01)

DNA polymerase ε and δ exonuclease domain mutations in endometrial cancer.
nork: Church, D, et al.
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Somatic POLE exonuclease domain mutations are early events in sporadic endometrial and colorectal carcinogenesis, determining driver mutational landscape, clonal neo-antigen burden and immune response
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POLE and POLD1 germline exonuclease domain pathogenic variants, a rare event in colorectal cancer from the Middle East
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Somatic POLE proofreading domain mutation, immune response and prognosis in colorectal cancer: a retrospective, pooled biomarker study
nork: Domingo, E, et al.
Argitaratua: (2016)

POLE proofreading domain mutation defines a subset of immunogenic colorectal cancers with excellent prognosis
nork: Glaire, MA, et al.
Argitaratua: (2016)

Rationale and design of the POLEM trial: avelumab plus fluoropyrimidine-based chemotherapy as adjuvant treatment for stage III mismatch repair deficient or POLE exonuclease domain mutant colon cancer: a phase III randomised study
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Argitaratua: (2020)

DmWRNexo is a 3'-5' exonuclease: phenotypic and biochemical characterization of mutants of the Drosophila orthologue of human WRN exonuclease.
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Adjuvant treatment for POLE proofreading domain-mutant cancers: sensitivity to radiotherapy, chemotherapy, and nucleoside analogues
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To cleave or not and how? The DNA exonucleases and endonucleases in immunity
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Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas.
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Argitaratua: (2013)

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Retroelement decay by the exonuclease XRN1 is a viral mimicry dependency in cancer
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A specific domain within the 3′ untranslated region of Usutu virus confers resistance to the exonuclease ISG20
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POLE proofreading mutation, immune response and prognosis in endometrial cancer
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Argitaratua: (2015)

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POLE proofreading mutations elicit an anti-tumor immune response in endometrial cancer
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Argitaratua: (2015)

Interpretation of somatic POLE mutations in endometrial carcinoma
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Argitaratua: (2020)

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Argitaratua: (2011)

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Argitaratua: (2011)

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The Clinical and Pathological Characteristics of POLE-Mutated Endometrial Cancer: A Comprehensive Review
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Unveiling immunogenic characteristics and neoantigens in endometrial cancer with POLE hotspot mutations for improved immunotherapy
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Deep learning for dual detection of microsatellite instability and POLE mutations in colorectal cancer histopathology
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Argitaratua: (2012)

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Sae2 controls Mre11 endo- and exonuclease activities by different mechanisms
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Argitaratua: (1998-01-01)

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Argitaratua: (2024-07-01)

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nork: Tsou, N, et al.
Argitaratua: (2010)

Rolling Circle Amplification Integrating with Exonuclease-III-Assisted Color Reaction for Sensitive Telomerase Activity Analysis
nork: Xiaoya Liu, et al.
Argitaratua: (2024-12-01)

Identification and characterization of a Drosophila ortholog of WRN exonuclease that is required to maintain genome integrity.
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Argitaratua: (2008)