Functional analysis of POLE exonuclease domain mutations in cancer

Functional analysis of POLE exonuclease domain mutations in cancer

<p><em>POLE</em> encodes the polymerase and exonuclease domains of the leading strand replicase, DNA polymerase ε. Somatic and germline <em>POLE</em> exonuclease domain mutations (EDMs) occur in colorectal and endometrial cancer and are associated with tumour ultramutat...

תיאור מלא

מידע ביבליוגרפי
מחבר ראשי:	Rayner, E
מחברים אחרים:	Church, D
פורמט:	Thesis
יצא לאור:	2019

פריטים דומים

Prognostic benefit of POLE exonuclease domain mutations in endometrial cancer cannot be explained by increased sensitivity to adjuvant treatment strategies
מאת: Van Gool, I, et al.
יצא לאור: (2017)

Somatic POLE exonuclease domain mutations elicit enhanced intratumoral immune responses in stage II colorectal cancer
מאת: Dan Huang, et al.
יצא לאור: (2020-10-01)

DNA polymerase ε and δ exonuclease domain mutations in endometrial cancer.
מאת: Church, D, et al.
יצא לאור: (2013)

Somatic POLE exonuclease domain mutations are early events in sporadic endometrial and colorectal carcinogenesis, determining driver mutational landscape, clonal neo-antigen burden and immune response
מאת: Temko, D, et al.
יצא לאור: (2018)

POLE and POLD1 germline exonuclease domain pathogenic variants, a rare event in colorectal cancer from the Middle East
מאת: Abdul K. Siraj, et al.
יצא לאור: (2020-08-01)

Characterisation of DNA polymerase δ exonuclease domain mutations associated with cancer predisposition using fission yeast
מאת: Toumazou, SI
יצא לאור: (2021)

Somatic POLE proofreading domain mutation, immune response and prognosis in colorectal cancer: a retrospective, pooled biomarker study
מאת: Domingo, E, et al.
יצא לאור: (2016)

POLE proofreading domain mutation defines a subset of immunogenic colorectal cancers with excellent prognosis
מאת: Glaire, MA, et al.
יצא לאור: (2016)

Rationale and design of the POLEM trial: avelumab plus fluoropyrimidine-based chemotherapy as adjuvant treatment for stage III mismatch repair deficient or POLE exonuclease domain mutant colon cancer: a phase III randomised study
מאת: Lau, D, et al.
יצא לאור: (2020)

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יצא לאור: (2009)

Adjuvant treatment for POLE proofreading domain-mutant cancers: sensitivity to radiotherapy, chemotherapy, and nucleoside analogues
מאת: Van Gool, I, et al.
יצא לאור: (2018)

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מאת: Mingjun Lu, et al.
יצא לאור: (2025-03-01)

Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas.
מאת: Palles, C, et al.
יצא לאור: (2013)

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יצא לאור: (2024-10-01)

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מאת: Van Gool, I, et al.
יצא לאור: (2015)

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יצא לאור: (2016)

POLE proofreading mutations elicit an anti-tumor immune response in endometrial cancer
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יצא לאור: (2015)

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יצא לאור: (2024-05-01)

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מאת: Hao Wang, et al.
יצא לאור: (2024-07-01)

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מאת: Tsou, N, et al.
יצא לאור: (2010)

Rolling Circle Amplification Integrating with Exonuclease-III-Assisted Color Reaction for Sensitive Telomerase Activity Analysis
מאת: Xiaoya Liu, et al.
יצא לאור: (2024-12-01)

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