Functional analysis of POLE exonuclease domain mutations in cancer

Functional analysis of POLE exonuclease domain mutations in cancer

<p><em>POLE</em> encodes the polymerase and exonuclease domains of the leading strand replicase, DNA polymerase ε. Somatic and germline <em>POLE</em> exonuclease domain mutations (EDMs) occur in colorectal and endometrial cancer and are associated with tumour ultramutat...

書誌詳細
第一著者:	Rayner, E
その他の著者:	Church, D
フォーマット:	学位論文
出版事項:	2019

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