Functional analysis of POLE exonuclease domain mutations in cancer

Functional analysis of POLE exonuclease domain mutations in cancer

<p><em>POLE</em> encodes the polymerase and exonuclease domains of the leading strand replicase, DNA polymerase ε. Somatic and germline <em>POLE</em> exonuclease domain mutations (EDMs) occur in colorectal and endometrial cancer and are associated with tumour ultramutat...

ver descrição completa

Detalhes bibliográficos
Autor principal:	Rayner, E
Outros Autores:	Church, D
Formato:	Thesis
Publicado em:	2019

Registos relacionados

Prognostic benefit of POLE exonuclease domain mutations in endometrial cancer cannot be explained by increased sensitivity to adjuvant treatment strategies
Por: Van Gool, I, et al.
Publicado em: (2017)

Somatic POLE exonuclease domain mutations elicit enhanced intratumoral immune responses in stage II colorectal cancer
Por: Dan Huang, et al.
Publicado em: (2020-10-01)

DNA polymerase ε and δ exonuclease domain mutations in endometrial cancer.
Por: Church, D, et al.
Publicado em: (2013)

Somatic POLE exonuclease domain mutations are early events in sporadic endometrial and colorectal carcinogenesis, determining driver mutational landscape, clonal neo-antigen burden and immune response
Por: Temko, D, et al.
Publicado em: (2018)

POLE and POLD1 germline exonuclease domain pathogenic variants, a rare event in colorectal cancer from the Middle East
Por: Abdul K. Siraj, et al.
Publicado em: (2020-08-01)

Characterisation of DNA polymerase δ exonuclease domain mutations associated with cancer predisposition using fission yeast
Por: Toumazou, SI
Publicado em: (2021)

Somatic POLE proofreading domain mutation, immune response and prognosis in colorectal cancer: a retrospective, pooled biomarker study
Por: Domingo, E, et al.
Publicado em: (2016)

POLE proofreading domain mutation defines a subset of immunogenic colorectal cancers with excellent prognosis
Por: Glaire, MA, et al.
Publicado em: (2016)

Rationale and design of the POLEM trial: avelumab plus fluoropyrimidine-based chemotherapy as adjuvant treatment for stage III mismatch repair deficient or POLE exonuclease domain mutant colon cancer: a phase III randomised study
Por: Lau, D, et al.
Publicado em: (2020)

DmWRNexo is a 3'-5' exonuclease: phenotypic and biochemical characterization of mutants of the Drosophila orthologue of human WRN exonuclease.
Por: Boubriak, I, et al.
Publicado em: (2009)

Adjuvant treatment for POLE proofreading domain-mutant cancers: sensitivity to radiotherapy, chemotherapy, and nucleoside analogues
Por: Van Gool, I, et al.
Publicado em: (2018)

To cleave or not and how? The DNA exonucleases and endonucleases in immunity
Por: Mingjun Lu, et al.
Publicado em: (2025-03-01)

Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas.
Por: Palles, C, et al.
Publicado em: (2013)

Retroelement decay by the exonuclease XRN1 is a viral mimicry dependency in cancer
Por: Hosseini, A, et al.
Publicado em: (2024)

Retroelement decay by the exonuclease XRN1 is a viral mimicry dependency in cancer
Por: Amir Hosseini, et al.
Publicado em: (2024-02-01)

A specific domain within the 3′ untranslated region of Usutu virus confers resistance to the exonuclease ISG20
Por: Jim Zoladek, et al.
Publicado em: (2024-10-01)

POLE proofreading mutation, immune response and prognosis in endometrial cancer
Por: Van Gool, I, et al.
Publicado em: (2015)

A panoply of errors: polymerase proofreading domain mutations in cancer
Por: Rayner, E, et al.
Publicado em: (2016)

POLE proofreading mutations elicit an anti-tumor immune response in endometrial cancer
Por: Klenerman, P, et al.
Publicado em: (2015)

Interpretation of somatic POLE mutations in endometrial carcinoma
Por: León-Castillo, A, et al.
Publicado em: (2020)

The role of DNA exonucleases in protecting genome stability and their impact on ageing
Por: Mason, P, et al.
Publicado em: (2011)

The role of DNA exonucleases in protecting genome stability and their impact on ageing.
Por: Mason, P, et al.
Publicado em: (2011)

Directed evolution of nucleotide-based libraries using lambda exonuclease
Por: Bee Nar Lim, et al.
Publicado em: (2012-12-01)

ePRINT: exonuclease assisted mapping of protein-RNA interactions
Por: Sophie Hawkins, et al.
Publicado em: (2024-05-01)

Exonuclease editor promotes precision of gene editing in mammalian cells
Por: Hui Shi, et al.
Publicado em: (2024-05-01)

The Clinical and Pathological Characteristics of POLE-Mutated Endometrial Cancer: A Comprehensive Review
Por: Yao X, et al.
Publicado em: (2024-03-01)

Structural basis of eukaryotic transcription termination by the Rat1 exonuclease complex
Por: Tatsuo Yanagisawa, et al.
Publicado em: (2024-09-01)

Compatible domain structures and the poling of single crystal ferroelectrics
Por: Tsou, N, et al.
Publicado em: (2010)

Unveiling immunogenic characteristics and neoantigens in endometrial cancer with POLE hotspot mutations for improved immunotherapy
Por: Jian Huang, et al.
Publicado em: (2025-01-01)

Deep learning for dual detection of microsatellite instability and POLE mutations in colorectal cancer histopathology
Por: Marco Gustav, et al.
Publicado em: (2024-05-01)

Recapitulation of Werner syndrome sensitivity to camptothecin by limited knockdown of the WRN helicase/exonuclease
Por: Bird, J, et al.
Publicado em: (2012)

Recapitulation of Werner syndrome sensitivity to camptothecin by limited knockdown of the WRN helicase/exonuclease.
Por: Bird, J, et al.
Publicado em: (2012)

Sae2 controls Mre11 endo- and exonuclease activities by different mechanisms
Por: Tomoki Tamai, et al.
Publicado em: (2024-08-01)

Vector-Swapping Strategy with an Exonuclease in Cloning and High Expression of Small PCR Products
Por: Masanobu Obara, et al.
Publicado em: (1998-01-01)

Exonuclease III-Generated Series of Homologous Competitor DNA Fragments for Competitive PCR
Por: Yoshiaki Iwasaki, et al.
Publicado em: (2000-08-01)

High-Throughput Single Nucleotide Polymorphism Genotyping by Fluorescent 5′ Exonuclease Assay
Por: Phillip A. Morin, et al.
Publicado em: (1999-09-01)

Bacterial exonuclease III expands its enzymatic activities on single-stranded DNA
Por: Hao Wang, et al.
Publicado em: (2024-07-01)

Compatible domain arrangements and poling ability in oriented ferroelectric films
Por: Tsou, N, et al.
Publicado em: (2010)

Rolling Circle Amplification Integrating with Exonuclease-III-Assisted Color Reaction for Sensitive Telomerase Activity Analysis
Por: Xiaoya Liu, et al.
Publicado em: (2024-12-01)

Identification and characterization of a Drosophila ortholog of WRN exonuclease that is required to maintain genome integrity.
Por: Saunders, R, et al.
Publicado em: (2008)