Tolerance induction with CD4 monoclonal antibodies.
One of the major goals of therapeutic immunosuppression is to be able to use short-term therapy to achieve long-term tolerance. Short courses of CD4 antibodies are able to create peripheral tolerance in a mature immune system. The resulting tolerant state shows evidence of being dominant in that one...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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1998
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| _version_ | 1797102295241981952 |
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| author | Waldmann, H Bemelman, F Cobbold, S |
| author_facet | Waldmann, H Bemelman, F Cobbold, S |
| author_sort | Waldmann, H |
| collection | OXFORD |
| description | One of the major goals of therapeutic immunosuppression is to be able to use short-term therapy to achieve long-term tolerance. Short courses of CD4 antibodies are able to create peripheral tolerance in a mature immune system. The resulting tolerant state shows evidence of being dominant in that one can observe the features of linked suppression, transferable suppression and infectious tolerance in a variety of model systems. Only in the situation of administration of high doses of marrow could one find evidence of central and peripheral tolerance which had all the features of being deletional rather than regulatory. These findings suggest that attaining dominant tolerance and linked suppression may be the least invasive of all tolerance-inducing strategies for clinical application. |
| first_indexed | 2024-03-07T06:03:56Z |
| format | Journal article |
| id | oxford-uuid:ed2e0d8f-17ef-4f95-86af-9df548539f33 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:03:56Z |
| publishDate | 1998 |
| record_format | dspace |
| spelling | oxford-uuid:ed2e0d8f-17ef-4f95-86af-9df548539f332022-03-27T11:22:56ZTolerance induction with CD4 monoclonal antibodies.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:ed2e0d8f-17ef-4f95-86af-9df548539f33EnglishSymplectic Elements at Oxford1998Waldmann, HBemelman, FCobbold, SOne of the major goals of therapeutic immunosuppression is to be able to use short-term therapy to achieve long-term tolerance. Short courses of CD4 antibodies are able to create peripheral tolerance in a mature immune system. The resulting tolerant state shows evidence of being dominant in that one can observe the features of linked suppression, transferable suppression and infectious tolerance in a variety of model systems. Only in the situation of administration of high doses of marrow could one find evidence of central and peripheral tolerance which had all the features of being deletional rather than regulatory. These findings suggest that attaining dominant tolerance and linked suppression may be the least invasive of all tolerance-inducing strategies for clinical application. |
| spellingShingle | Waldmann, H Bemelman, F Cobbold, S Tolerance induction with CD4 monoclonal antibodies. |
| title | Tolerance induction with CD4 monoclonal antibodies. |
| title_full | Tolerance induction with CD4 monoclonal antibodies. |
| title_fullStr | Tolerance induction with CD4 monoclonal antibodies. |
| title_full_unstemmed | Tolerance induction with CD4 monoclonal antibodies. |
| title_short | Tolerance induction with CD4 monoclonal antibodies. |
| title_sort | tolerance induction with cd4 monoclonal antibodies |
| work_keys_str_mv | AT waldmannh toleranceinductionwithcd4monoclonalantibodies AT bemelmanf toleranceinductionwithcd4monoclonalantibodies AT cobbolds toleranceinductionwithcd4monoclonalantibodies |