miR-21 mediates hematopoietic suppression in MDS by activating TGF-β signaling.

miR-21 mediates hematopoietic suppression in MDS by activating TGF-β signaling.

Myelodysplastic syndromes (MDS) are characterized by ineffective hematopoiesis that leads to peripheral cytopenias. We observed that SMAD7, a negative regulator of transforming growth factor-beta (TGF-β) receptor-I kinase, is markedly reduced in MDS and leads to ineffective hematopoiesis by overacti...

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Manylion Llyfryddiaeth
Prif Awduron:	Bhagat, T, Zhou, L, Sokol, L, Kessel, R, Caceres, G, Gundabolu, K, Tamari, R, Gordon, S, Mantzaris, I, Jodlowski, T, Yu, Y, Jing, X, Polineni, R, Bhatia, K, Pellagatti, A, Boultwood, J, Kambhampati, S, Steidl, U, Stein, C, Ju, W, Liu, G, Kenny, P, List, A, Bitzer, M, Verma, A
Fformat:	Conference item
Cyhoeddwyd:	American Society of Hematology 2013

Eitemau Tebyg

miR-21 mediates hematopoietic suppression in MDS by activating TGF-beta signaling
gan: Bhagat, T, et al.
Cyhoeddwyd: (2013)

Inhibition of the TGF-beta receptor I kinase promotes hematopoiesis in MDS.
gan: Zhou, L, et al.
Cyhoeddwyd: (2008)

Reduced SMAD7 leads to overactivation of TGF-beta signaling in MDS that can be reversed by a specific inhibitor of TGF-beta receptor I kinase.
gan: Zhou, L, et al.
Cyhoeddwyd: (2011)

TP53 suppression promotes erythropoiesis in del(5q) MDS, suggesting a targeted therapeutic strategy in lenalidomide-resistant patients.
gan: Caceres, G, et al.
Cyhoeddwyd: (2013)

Overexpression of IL-1 receptor accessory protein in stem and progenitor cells and outcome correlation in AML and MDS.
gan: Barreyro, L, et al.
Cyhoeddwyd: (2012)

Recent advances in MDS mutation landscape: splicing and signalling
gan: Follo, MY, et al.
Cyhoeddwyd: (2019)

Aberrant Expression of DOCK4 Leads to Disruption of the F-Actin Skeleton and Altered Membrane Stability in MDS Erythroblasts and Mature Erythrocytes
gan: Sundaravel, S, et al.
Cyhoeddwyd: (2012)

Aberrant Expression of DOCK4 Leads to Disruption of the F-Actin Skeleton and Altered Membrane Stability in MDS Erythroblasts and Mature Erythrocytes
gan: Sundaravel, S, et al.
Cyhoeddwyd: (2012)

Classification, risk stratification and response assessment in myelodysplastic syndromes/neoplasms (MDS): a state-of-the-art report on behalf of the International Consortium for MDS (icMDS)
gan: Stahl, M, et al.
Cyhoeddwyd: (2023)

Generalized GM-MDS: Polynomial Codes Are Higher Order MDS
gan: Brakensiek, Joshua, et al.
Cyhoeddwyd: (2024)

High-resolution genomic profiling of myelodysplasia (MDS) by microarray comparative genomic hybridisation (CGH)
gan: Esoof, N, et al.
Cyhoeddwyd: (2005)

High-resolution genomic profiling of myelodysplasia (MDS) by microarray comparative genomic hybridization (CGH).
gan: Esoof, N, et al.
Cyhoeddwyd: (2006)

Toward a more patient‐centered drug development process in clinical trials for patients with myelodysplastic syndromes/neoplasms (MDS): Practical considerations from the International Consortium for MDS (icMDS)
gan: Efficace, F, et al.
Cyhoeddwyd: (2024)

The weights in MDS codes
gan: Ezerman, Martianus Frederic, et al.
Cyhoeddwyd: (2019)

Application of classical Hermitian self-orthogonal MDS codes to quantum MDS codes
gan: Jin, Lingfei, et al.
Cyhoeddwyd: (2012)

Lenalidomide selectively inhibits in vitro growth of the malignant clone in myelodysplastic syndrome (MDS) patients with 5q deletion.
gan: Jadersten, M, et al.
Cyhoeddwyd: (2005)

Micro-environmental sensing by bone marrow stroma identifies IL-6 and TGFβ1 as regulators of hematopoietic ageing
gan: Valletta, S, et al.
Cyhoeddwyd: (2020)

Aberrant overexpression of CD14 on granulocytes sensitizes the innate immune response in mDia1 heterozygous del(5q) MDS.
gan: Keerthivasan, G, et al.
Cyhoeddwyd: (2014)

SF3B1-mutant MDS as a distinct disease subtype: a proposal from the International Working Group for the Prognosis of MDS
gan: Malcovati, L, et al.
Cyhoeddwyd: (2020)

New quantum MDS codes
gan: Zhang, Guanghui, et al.
Cyhoeddwyd: (2015)

Stem and progenitor cells in myelodysplastic syndromes show aberrant stage-specific expansion and harbor genetic and epigenetic alterations.
gan: Will, B, et al.
Cyhoeddwyd: (2012)

MDS-445 Magrolimab in combination with azacitidine for patients with untreated higher-risk myelodysplastic syndromes (HR MDS): 5F9005 phase 1b study results
gan: Sallman, D, et al.
Cyhoeddwyd: (2022)

Meta-analysis of microarray studies reveals a novel hematopoietic progenitor cell signature and demonstrates feasibility of inter-platform data integration
gan: Sohal, D, et al.
Cyhoeddwyd: (2008)

Minimizing risk of hypomethylating agent failure in patients with higher-risk MDS and practical management recommendations.
gan: Santini, V, et al.
Cyhoeddwyd: (2014)

Downregulation of Ribosomal Proteins Is Seen in Non 5q-MDS
gan: Sohal, P, et al.
Cyhoeddwyd: (2008)

Diffusion analysis of EFN-MDS structure
gan: Ibrahim, Subariah
Cyhoeddwyd: (2006)

Diffusion analysis of EFN-MDS structure
gan: Ibrahim, Subariah, et al.
Cyhoeddwyd: (2006)

MDS plus data acquisition system
gan: Stillerman, J.A., et al.
Cyhoeddwyd: (2015)

Gene expression profiling in MDS and AML: potential and future avenues.
gan: Theilgaard-Mönch, K, et al.
Cyhoeddwyd: (2011)

MiR‐135b is a direct PAX6 target and specifies human neuroectoderm by inhibiting TGF‐β/BMP signaling
gan: Bhinge, Akshay, et al.
Cyhoeddwyd: (2015)

DHPLC analysis of the ATRX gene in myelodysplastic syndrome (MDS) associated with acquired alpha thalassemia (AT-MDS): Novel mutation detection despite somatic mosaicism.
gan: Steensma, D, et al.
Cyhoeddwyd: (2003)

MDS-482 Impact of magrolimab in combination with azacitidine on red blood cells (RBCs) in patients with higher-risk myelodysplastic syndromes (HR MDS)
gan: Chen, J, et al.
Cyhoeddwyd: (2022)

GFI1(36N) as a therapeutic and prognostic marker for myelodysplastic syndrome (MDS)
gan: Botezatu, L, et al.
Cyhoeddwyd: (2016)

Trisomy X and myelodysplastic syndrome (MDS) with eosinophilia
gan: Mohd Tohit, Eusni Rahayu, et al.
Cyhoeddwyd: (2012)

Application of constacyclic codes to quantum MDS codes
gan: Chen, Bocong, et al.
Cyhoeddwyd: (2015)

A construction of MDS quantum convolutional codes
gan: Zhang, Guanghui, et al.
Cyhoeddwyd: (2015)

On linear codes whose hermitian hulls are MDS
gan: Luo, Gaojun, et al.
Cyhoeddwyd: (2024)

Deregulated Gene Expression Pathways in Myelodysplastic Syndrome Hematopoietic Stem Cells
gan: Pellagatti, A, et al.
Cyhoeddwyd: (2009)

Deregulated gene expression pathways in myelodysplastic syndrome hematopoietic stem cells.
gan: Pellagatti, A, et al.
Cyhoeddwyd: (2010)

Response of high-risk MDS to azacitidine and lenalidomide is impacted by baseline and acquired mutations in a cluster of three inositide-specific genes
gan: Follo, M, et al.
Cyhoeddwyd: (2019)