miR-21 mediates hematopoietic suppression in MDS by activating TGF-β signaling.
Myelodysplastic syndromes (MDS) are characterized by ineffective hematopoiesis that leads to peripheral cytopenias. We observed that SMAD7, a negative regulator of transforming growth factor-beta (TGF-β) receptor-I kinase, is markedly reduced in MDS and leads to ineffective hematopoiesis by overacti...
প্রধান লেখক: | Bhagat, T, Zhou, L, Sokol, L, Kessel, R, Caceres, G, Gundabolu, K, Tamari, R, Gordon, S, Mantzaris, I, Jodlowski, T, Yu, Y, Jing, X, Polineni, R, Bhatia, K, Pellagatti, A, Boultwood, J, Kambhampati, S, Steidl, U, Stein, C, Ju, W, Liu, G, Kenny, P, List, A, Bitzer, M, Verma, A |
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বিন্যাস: | Conference item |
প্রকাশিত: |
American Society of Hematology
2013
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অনুরূপ উপাদানগুলি
অনুরূপ উপাদানগুলি
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miR-21 mediates hematopoietic suppression in MDS by activating TGF-beta signaling
অনুযায়ী: Bhagat, T, অন্যান্য
প্রকাশিত: (2013) -
Inhibition of the TGF-beta receptor I kinase promotes hematopoiesis in MDS.
অনুযায়ী: Zhou, L, অন্যান্য
প্রকাশিত: (2008) -
Reduced SMAD7 leads to overactivation of TGF-beta signaling in MDS that can be reversed by a specific inhibitor of TGF-beta receptor I kinase.
অনুযায়ী: Zhou, L, অন্যান্য
প্রকাশিত: (2011) -
The impact of spliceosome mutations in MDS
অনুযায়ী: Jacqueline Boultwood, অন্যান্য
প্রকাশিত: (2019-06-01) -
TP53 suppression promotes erythropoiesis in del(5q) MDS, suggesting a targeted therapeutic strategy in lenalidomide-resistant patients.
অনুযায়ী: Caceres, G, অন্যান্য
প্রকাশিত: (2013)