miR-21 mediates hematopoietic suppression in MDS by activating TGF-β signaling.

miR-21 mediates hematopoietic suppression in MDS by activating TGF-β signaling.

Myelodysplastic syndromes (MDS) are characterized by ineffective hematopoiesis that leads to peripheral cytopenias. We observed that SMAD7, a negative regulator of transforming growth factor-beta (TGF-β) receptor-I kinase, is markedly reduced in MDS and leads to ineffective hematopoiesis by overacti...

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Bibliographic Details
Main Authors: Bhagat, T, Zhou, L, Sokol, L, Kessel, R, Caceres, G, Gundabolu, K, Tamari, R, Gordon, S, Mantzaris, I, Jodlowski, T, Yu, Y, Jing, X, Polineni, R, Bhatia, K, Pellagatti, A, Boultwood, J, Kambhampati, S, Steidl, U, Stein, C, Ju, W, Liu, G, Kenny, P, List, A, Bitzer, M, Verma, A
Format: Conference item
Published: American Society of Hematology 2013

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