miR-21 mediates hematopoietic suppression in MDS by activating TGF-β signaling.
Myelodysplastic syndromes (MDS) are characterized by ineffective hematopoiesis that leads to peripheral cytopenias. We observed that SMAD7, a negative regulator of transforming growth factor-beta (TGF-β) receptor-I kinase, is markedly reduced in MDS and leads to ineffective hematopoiesis by overacti...
Главные авторы: | , , , , , , , , , , , , , , , , , , , , , , , , |
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Формат: | Conference item |
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American Society of Hematology
2013
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