The transfer of a laboratory based hypothesis to a clinically useful therapy: the development of anti-TNF therapy of rheumatoid arthritis.

The development of anti-TNF therapy is a key step forward in rheumatology as it is the first new therapy for based on investigating the molecular mechanisms of this disease. This chapter reviews how this discovery was made.

Dades bibliogràfiques
Autors principals:	Feldmann, M, Brennan, F, Williams, R, Woody, J, Maini, R
Format:	Journal article
Idioma:	English
Publicat:	2004

Ítems similars

ANTI TNF THERAPY IN RHEUMATOID ARTHRITIS
per: Feldmann, M, et al.
Publicat: (2011)

TNF-alpha in rheumatoid arthritis and prospects of anti-TNF therapy.
per: Maini, R, et al.
Publicat: (1993)

Targeting TNF alpha for the therapy of rheumatoid arthritis.
per: Maini, R, et al.
Publicat: (1994)

TNF blockade in rheumatoid arthritis: implications for therapy and pathogenesis.
per: Maini, R, et al.
Publicat: (1997)

Insights into the pathogenesis of rheumatoid arthritis from application of anti-TNF therapy.
per: Maini, R, et al.
Publicat: (2000)

Anti-TNF alpha therapy of rheumatoid arthritis: what have we learned?
per: Feldmann, M, et al.
Publicat: (2001)

Cytokine expression and networks in rheumatoid arthritis: rationale for anti-TNF alpha antibody therapy and its mechanism of action.
per: Feldmann, M, et al.
Publicat: (1995)

Anti-tumor necrosis factor-alpha therapy of rheumatoid arthritis.
per: Feldmann, M, et al.
Publicat: (1997)

Development of anti-TNF therapy for rheumatoid arthritis.
per: Feldmann, M
Publicat: (2002)

Anti-TNF alpha therapy in rheumatoid arthritis--current and future directions.
per: Taylor, P, et al.
Publicat: (2000)

From the laboratory to the clinic: Evaluation of cytokines in rheumatoid arthritis highlights TNF-alpha as a new therapeutic target
per: Feldmann, M, et al.
Publicat: (1994)

Anti-TNFalpha therapy of rheumatoid arthritis: what can we learn about chronic disease?
per: Feldmann, M, et al.
Publicat: (2004)

TNF alpha is an effective therapeutic target for rheumatoid arthritis.
per: Feldmann, M, et al.
Publicat: (1995)

TNFα - A pivotal role in rheumatoid arthritis?
per: Brennan, F, et al.
Publicat: (1992)

TNF alpha--a pivotal role in rheumatoid arthritis?
per: Brennan, F, et al.
Publicat: (1992)

The role of TNF alpha and IL-1 in rheumatoid arthritis.
per: Feldmann, M, et al.
Publicat: (2001)

Anti-TNF biologic agents: still the therapy of choice for rheumatoid arthritis.
per: Taylor, P, et al.
Publicat: (2009)

Cytokine therapy in rheumatoid arthritis.
per: Maini, R, et al.
Publicat: (1996)

Regulation of cytokines, cytokine inhibitors, and acute-phase proteins following anti-TNF-alpha therapy in rheumatoid arthritis.
per: Charles, P, et al.
Publicat: (1999)

TNF alpha as a therapeutic target in rheumatoid arthritis.
per: Feldmann, M, et al.
Publicat: (1994)

Monoclonal anti-TNF alpha antibody as a probe of pathogenesis and therapy of rheumatoid disease.
per: Maini, R, et al.
Publicat: (1995)

Anti-tumor necrosis factor alpha therapy of rheumatoid arthritis. Mechanism of action.
per: Feldmann, M, et al.
Publicat: (1997)

Evaluation of TNF-alpha and IL-1 blockade in collagen-induced arthritis and comparison with combined anti-TNF-alpha/anti-CD4 therapy.
per: Williams, R, et al.
Publicat: (2000)

Discovery of TNF-alpha as a therapeutic target in rheumatoid arthritis: preclinical and clinical studies.
per: Feldmann, M, et al.
Publicat: (2002)

Discovery of TNF-α as a therapeutic target in rheumatoid arthritis: Preclinical and clinical studies
per: Feldmann, M, et al.
Publicat: (2002)

Anti-TNF therapy: where have we got to in 2005?
per: Feldmann, M, et al.
Publicat: (2005)

Anti-cytokine therapy for rheumatoid arthritis.
per: Maini, R, et al.
Publicat: (2000)

TNFα blockade in rheumatoid arthritis: Rationale, clinical outcomes and mechanisms of action
per: Elliott, M, et al.
Publicat: (1995)

TNF alpha blockade in rheumatoid arthritis: rationale, clinical outcomes and mechanisms of action.
per: Elliott, M, et al.
Publicat: (1995)

Evaluation of the role of cytokines in autoimmune disease: the importance of TNF alpha in rheumatoid arthritis.
per: Feldmann, M, et al.
Publicat: (1992)

Clinical and functional effectiveness of anti-TNF therapy in patients with rheumatoid arthritis
per: Martínez-Pérez Rosalia, et al.
Publicat: (2011-11-01)

Anti-TNF alpha therapy is useful in rheumatoid arthritis and Crohn's disease: analysis of the mechanism of action predicts utility in other diseases.
per: Feldman, M, et al.
Publicat: (1998)

Successful therapy of collagen-induced arthritis with TNF receptor-IgG fusion protein and combination with anti-CD4.
per: Williams, R, et al.
Publicat: (1995)

Beneficial effects of tumour necrosis factor-alpha (TNF-alpha) blockade in rheumatoid arthritis (RA)
per: Maini, R, et al.
Publicat: (1995)

Rheumatoid arthritis.
per: Feldmann, M, et al.
Publicat: (1996)

Biological insights from clinical trials with anti-TNF therapy.
per: Feldmann, M, et al.
Publicat: (1998)

TNF defined as a therapeutic target for rheumatoid arthritis and other autoimmune diseases
per: Feldmann, M, et al.
Publicat: (2003)

Serum adiponectin as a predictor of laboratory response to anti-TNF-α therapy in rheumatoid arthritis
per: Dorota Sikorska, et al.
Publicat: (2018-10-01)

Anti-TNF therapy for rheumatoid arthritis and other inflammatory diseases.
per: Taylor, P
Publicat: (2001)

Inhibitory effect of TNF alpha antibodies on synovial cell interleukin-1 production in rheumatoid arthritis.
per: Brennan, F, et al.
Publicat: (1989)