Poly(ADP-ribosyl)ation of FOXP3 protein mediated by PARP-1 protein regulates the function of regulatory T cells

Poly(ADP-ribosyl)ation of FOXP3 protein mediated by PARP-1 protein regulates the function of regulatory T cells

Poly(ADP-ribose) polymerase 1 (PARP-1) is an ADP-ribosylating enzyme participating in diverse cellular functions. The roles of PARP-1 in the immune system, however, have not been well understood. Here we find that PARP-1 interacts with FOXP3 and induces its poly(ADP-ribosyl)ation. By using PARP-1 in...

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Những tác giả chính:	Luo, X, Nie, J, Wang, S, Chen, Z, Chen, W, Li, D, Hu, H, Li, B
Định dạng:	Journal article
Ngôn ngữ:	English
Được phát hành:	Elsevier 2015

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