Evidence for a sliding-resistance at the tip of the trypanosome flagellum.

Motility in trypanosomes is achieved through the undulating behaviour of a single "9 + 2" flagellum; normally the flagellar waves begin at the flagellar tip and propagate towards the base. For flagella in general, however, propagation is from base-to-tip and it is believed that bend format...

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Autori principali: Woolley, D, Gadelha, C, Gull, K
Natura: Journal article
Lingua:English
Pubblicazione: 2006
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author Woolley, D
Gadelha, C
Gull, K
author_facet Woolley, D
Gadelha, C
Gull, K
author_sort Woolley, D
collection OXFORD
description Motility in trypanosomes is achieved through the undulating behaviour of a single "9 + 2" flagellum; normally the flagellar waves begin at the flagellar tip and propagate towards the base. For flagella in general, however, propagation is from base-to-tip and it is believed that bend formation, and sustained regular oscillation, depend upon a localised resistance to inter-doublet sliding - which is normally conferred by structures at the flagellar base, typically the basal body. We therefore predicted that in trypanosomes there must be a resistive structure at the flagellar tip. Electron micrographs of Crithidia deanei, Herpetomonas megaseliae, Trypanosoma brucei and Leishmania major have confirmed that such attachments are present. Thus, it can be assumed that in trypanosomes microtubule sliding at the flagellar tip is resisted sufficiently to permit bend formation.
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spelling oxford-uuid:ed6e08e1-c06e-45fd-b42c-498b88d1b59e2022-03-27T11:24:57ZEvidence for a sliding-resistance at the tip of the trypanosome flagellum.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:ed6e08e1-c06e-45fd-b42c-498b88d1b59eEnglishSymplectic Elements at Oxford2006Woolley, DGadelha, CGull, KMotility in trypanosomes is achieved through the undulating behaviour of a single "9 + 2" flagellum; normally the flagellar waves begin at the flagellar tip and propagate towards the base. For flagella in general, however, propagation is from base-to-tip and it is believed that bend formation, and sustained regular oscillation, depend upon a localised resistance to inter-doublet sliding - which is normally conferred by structures at the flagellar base, typically the basal body. We therefore predicted that in trypanosomes there must be a resistive structure at the flagellar tip. Electron micrographs of Crithidia deanei, Herpetomonas megaseliae, Trypanosoma brucei and Leishmania major have confirmed that such attachments are present. Thus, it can be assumed that in trypanosomes microtubule sliding at the flagellar tip is resisted sufficiently to permit bend formation.
spellingShingle Woolley, D
Gadelha, C
Gull, K
Evidence for a sliding-resistance at the tip of the trypanosome flagellum.
title Evidence for a sliding-resistance at the tip of the trypanosome flagellum.
title_full Evidence for a sliding-resistance at the tip of the trypanosome flagellum.
title_fullStr Evidence for a sliding-resistance at the tip of the trypanosome flagellum.
title_full_unstemmed Evidence for a sliding-resistance at the tip of the trypanosome flagellum.
title_short Evidence for a sliding-resistance at the tip of the trypanosome flagellum.
title_sort evidence for a sliding resistance at the tip of the trypanosome flagellum
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AT gadelhac evidenceforaslidingresistanceatthetipofthetrypanosomeflagellum
AT gullk evidenceforaslidingresistanceatthetipofthetrypanosomeflagellum