The importance of p53 pathway genetics in inherited and somatic cancer genomes
Decades of research have shown that mutations in the p53 stress response pathway affect the incidence of diverse cancers more than mutations in other pathways. However, most evidence is limited to somatic mutations and rare inherited mutations. Using newly abundant genomic data, we demonstrate that...
| Asıl Yazarlar: | , , , , , , , , , , , , , , , , , , |
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| Materyal Türü: | Journal article |
| Dil: | English |
| Baskı/Yayın Bilgisi: |
Nature Publishing Group
2016
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| _version_ | 1826303570079645696 |
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| author | Stracquadanio, G Wang, X Wallace, M Grawenda, A Zhang, P Hewitt, J Zeron-Medina, J Castro-Giner, F Tomlinson, I Goding, C Cygan, K Fairbrother, W Thomas, L Saetrom, P Gemignani, F Landi, S Schuster-Boeckler, B Bell, D Bond, G |
| author_facet | Stracquadanio, G Wang, X Wallace, M Grawenda, A Zhang, P Hewitt, J Zeron-Medina, J Castro-Giner, F Tomlinson, I Goding, C Cygan, K Fairbrother, W Thomas, L Saetrom, P Gemignani, F Landi, S Schuster-Boeckler, B Bell, D Bond, G |
| author_sort | Stracquadanio, G |
| collection | OXFORD |
| description | Decades of research have shown that mutations in the p53 stress response pathway affect the incidence of diverse cancers more than mutations in other pathways. However, most evidence is limited to somatic mutations and rare inherited mutations. Using newly abundant genomic data, we demonstrate that commonly inherited genetic variants in the p53 pathway also affect the incidence of a broad range of cancers more than variants in other pathways. The cancer-associated single nucleotide polymorphisms (SNPs) of the p53 pathway have strikingly similar genetic characteristics to well-studied p53 pathway cancer-causing somatic mutations. Our results enable insights into p53-mediated tumour suppression in humans and into p53 pathway-based cancer surveillance and treatment strategies. |
| first_indexed | 2024-03-07T06:04:42Z |
| format | Journal article |
| id | oxford-uuid:ed6eff37-48de-4029-b259-2a453745fb40 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:04:42Z |
| publishDate | 2016 |
| publisher | Nature Publishing Group |
| record_format | dspace |
| spelling | oxford-uuid:ed6eff37-48de-4029-b259-2a453745fb402022-03-27T11:25:04ZThe importance of p53 pathway genetics in inherited and somatic cancer genomesJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:ed6eff37-48de-4029-b259-2a453745fb40EnglishSymplectic Elements at OxfordNature Publishing Group2016Stracquadanio, GWang, XWallace, MGrawenda, AZhang, PHewitt, JZeron-Medina, JCastro-Giner, FTomlinson, IGoding, CCygan, KFairbrother, WThomas, LSaetrom, PGemignani, FLandi, SSchuster-Boeckler, BBell, DBond, GDecades of research have shown that mutations in the p53 stress response pathway affect the incidence of diverse cancers more than mutations in other pathways. However, most evidence is limited to somatic mutations and rare inherited mutations. Using newly abundant genomic data, we demonstrate that commonly inherited genetic variants in the p53 pathway also affect the incidence of a broad range of cancers more than variants in other pathways. The cancer-associated single nucleotide polymorphisms (SNPs) of the p53 pathway have strikingly similar genetic characteristics to well-studied p53 pathway cancer-causing somatic mutations. Our results enable insights into p53-mediated tumour suppression in humans and into p53 pathway-based cancer surveillance and treatment strategies. |
| spellingShingle | Stracquadanio, G Wang, X Wallace, M Grawenda, A Zhang, P Hewitt, J Zeron-Medina, J Castro-Giner, F Tomlinson, I Goding, C Cygan, K Fairbrother, W Thomas, L Saetrom, P Gemignani, F Landi, S Schuster-Boeckler, B Bell, D Bond, G The importance of p53 pathway genetics in inherited and somatic cancer genomes |
| title | The importance of p53 pathway genetics in inherited and somatic cancer genomes |
| title_full | The importance of p53 pathway genetics in inherited and somatic cancer genomes |
| title_fullStr | The importance of p53 pathway genetics in inherited and somatic cancer genomes |
| title_full_unstemmed | The importance of p53 pathway genetics in inherited and somatic cancer genomes |
| title_short | The importance of p53 pathway genetics in inherited and somatic cancer genomes |
| title_sort | importance of p53 pathway genetics in inherited and somatic cancer genomes |
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