Validation of the survival model including cardiac substructure dosimetry in NSCLC

In lung cancer radiotherapy (RT) high doses are delivered to the heart. We found significant associations between death rate (DR) and high left atrial wall (LAWall) volumes receiving 63-69Gy (LAWallV63-69) and any new or worsening ischaemic or rhythm ECG changes within 6 months of RT in a prospectiv...

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Bibliographic Details
Main Authors: Vivekanandan, S, Panakis, N, Higgins, G, Stuart, R, Landau, D, Cooke, R, Chu, K, Fresen, J, Fenwick, J, Hawkins, M
Format: Conference item
Published: Elsevier 2018
Description
Summary:In lung cancer radiotherapy (RT) high doses are delivered to the heart. We found significant associations between death rate (DR) and high left atrial wall (LAWall) volumes receiving 63-69Gy (LAWallV63-69) and any new or worsening ischaemic or rhythm ECG changes within 6 months of RT in a prospective isotoxic dose-escalation trial of 78 locally advanced non-small cell lung cancer (LA-NSCLC) patients. Here we aim to validate these findings in an independent retrospective cohort.