Validation of the survival model including cardiac substructure dosimetry in NSCLC
In lung cancer radiotherapy (RT) high doses are delivered to the heart. We found significant associations between death rate (DR) and high left atrial wall (LAWall) volumes receiving 63-69Gy (LAWallV63-69) and any new or worsening ischaemic or rhythm ECG changes within 6 months of RT in a prospectiv...
| Main Authors: | , , , , , , , , , |
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| Format: | Conference item |
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Elsevier
2018
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| _version_ | 1797102350846918656 |
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| author | Vivekanandan, S Panakis, N Higgins, G Stuart, R Landau, D Cooke, R Chu, K Fresen, J Fenwick, J Hawkins, M |
| author_facet | Vivekanandan, S Panakis, N Higgins, G Stuart, R Landau, D Cooke, R Chu, K Fresen, J Fenwick, J Hawkins, M |
| author_sort | Vivekanandan, S |
| collection | OXFORD |
| description | In lung cancer radiotherapy (RT) high doses are delivered to the heart. We found significant associations between death rate (DR) and high left atrial wall (LAWall) volumes receiving 63-69Gy (LAWallV63-69) and any new or worsening ischaemic or rhythm ECG changes within 6 months of RT in a prospective isotoxic dose-escalation trial of 78 locally advanced non-small cell lung cancer (LA-NSCLC) patients. Here we aim to validate these findings in an independent retrospective cohort. |
| first_indexed | 2024-03-07T06:04:45Z |
| format | Conference item |
| id | oxford-uuid:ed73b7c5-758d-4a9f-ab2e-dc09af9c68ea |
| institution | University of Oxford |
| last_indexed | 2024-03-07T06:04:45Z |
| publishDate | 2018 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:ed73b7c5-758d-4a9f-ab2e-dc09af9c68ea2022-03-27T11:25:10ZValidation of the survival model including cardiac substructure dosimetry in NSCLCConference itemhttp://purl.org/coar/resource_type/c_5794uuid:ed73b7c5-758d-4a9f-ab2e-dc09af9c68eaSymplectic Elements at OxfordElsevier2018Vivekanandan, SPanakis, NHiggins, GStuart, RLandau, DCooke, RChu, KFresen, JFenwick, JHawkins, MIn lung cancer radiotherapy (RT) high doses are delivered to the heart. We found significant associations between death rate (DR) and high left atrial wall (LAWall) volumes receiving 63-69Gy (LAWallV63-69) and any new or worsening ischaemic or rhythm ECG changes within 6 months of RT in a prospective isotoxic dose-escalation trial of 78 locally advanced non-small cell lung cancer (LA-NSCLC) patients. Here we aim to validate these findings in an independent retrospective cohort. |
| spellingShingle | Vivekanandan, S Panakis, N Higgins, G Stuart, R Landau, D Cooke, R Chu, K Fresen, J Fenwick, J Hawkins, M Validation of the survival model including cardiac substructure dosimetry in NSCLC |
| title | Validation of the survival model including cardiac substructure dosimetry in NSCLC |
| title_full | Validation of the survival model including cardiac substructure dosimetry in NSCLC |
| title_fullStr | Validation of the survival model including cardiac substructure dosimetry in NSCLC |
| title_full_unstemmed | Validation of the survival model including cardiac substructure dosimetry in NSCLC |
| title_short | Validation of the survival model including cardiac substructure dosimetry in NSCLC |
| title_sort | validation of the survival model including cardiac substructure dosimetry in nsclc |
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