Splicing factor gene mutations in the myelodysplastic syndromes: impact on disease phenotype and therapeutic applications.

Splicing factor gene mutations in the myelodysplastic syndromes: impact on disease phenotype and therapeutic applications.

Splicing factor gene mutations are the most frequent mutations found in patients with the myeloid malignancy myelodysplastic syndrome (MDS), suggesting that spliceosomal dysfunction plays a major role in disease pathogenesis. The aberrantly spliced target genes and deregulated cellular pathways asso...

תיאור מלא

מידע ביבליוגרפי
Main Authors:	Pellagatti, A, Boultwood, J
פורמט:	Journal article
שפה:	English
יצא לאור:	Elsevier 2016

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