Splicing factor gene mutations in the myelodysplastic syndromes: impact on disease phenotype and therapeutic applications.

Splicing factor gene mutations in the myelodysplastic syndromes: impact on disease phenotype and therapeutic applications.

Splicing factor gene mutations are the most frequent mutations found in patients with the myeloid malignancy myelodysplastic syndrome (MDS), suggesting that spliceosomal dysfunction plays a major role in disease pathogenesis. The aberrantly spliced target genes and deregulated cellular pathways asso...

書誌詳細
主要な著者:	Pellagatti, A, Boultwood, J
フォーマット:	Journal article
言語:	English
出版事項:	Elsevier 2016

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