Distinct moieties underlie biphasic H+ gating of connexin43 channels, producing a pH optimum for intercellular communication

Distinct moieties underlie biphasic H+ gating of connexin43 channels, producing a pH optimum for intercellular communication

Most mammalian cells can intercommunicate via connexin-assembled, gap-junctional channels. To regulate signal transmission, connexin (Cx) channel permeability must respond dynamically to physiological and pathophysiological stimuli. One key stimulus is intracellular pH (pHi), which is modulated by a...

Полное описание

Библиографические подробности
Главные авторы:	Garciarena, C, Malik, A, Swietach, P, Moreno, A, Vaughan-Jones, R
Формат:	Journal article
Опубликовано:	Federation of American Society of Experimental Biology 2018

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